Inflammation and tumor progression: signaling pathways and targeted intervention
H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …
The hallmarks of cancer immune evasion
According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
Emerging functions of IL-33 in homeostasis and immunity
GK Dwyer, LM D'Cruz… - Annual review of …, 2022 - annualreviews.org
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …
Interleukin-33 in health and disease
FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …
Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression
S Taniguchi, A Elhance, A Van Duzer, S Kumar… - Science, 2020 - science.org
INTRODUCTION A small subset of tumor cells with long-term tumorigenic capacity, known
as tumor-initiating cells (TICs), play a pivotal role in cancer development and therapy …
as tumor-initiating cells (TICs), play a pivotal role in cancer development and therapy …
The ST2/IL-33 axis in immune cells during inflammatory diseases
B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
IL-1 family members in cancer; two sides to every story
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
Alarmins and immunity
D Yang, Z Han, JJ Oppenheim - Immunological reviews, 2017 - Wiley Online Library
More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The
alarmin family has been expanding in terms of both number and the concept. It has recently …
alarmin family has been expanding in terms of both number and the concept. It has recently …
Interleukin-33 in tissue homeostasis, injury, and inflammation
AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …