Following the discovery of inositol-1, 4, 5-trisphosphate as a second messenger, many other
inositol phosphates were discovered in quick succession, with some understanding of their …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

Histone deacetylase enzymes (HDACs) are emerging cancer drug targets. They regulate
gene expression by removing acetyl groups from lysine residues in histone tails, resulting in …

Abstract Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large
transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in …

Inositol phospholipids and inositol phosphates mediate well‐established functions in signal
transduction and in Ca2+ homeostasis in the CNS and non‐neural tissues. More recently …

myo-Inositol-1, 2, 3, 4, 5, 6-hexakisphosphate (Ins P6) was first described as an abundant
form of phosphorus in plant seeds and other plant tissues and dubbed “phytic acid” …

▪ Abstract The existence and function of actin in the nucleus has been hotly debated for forty
years. Recently, β-actin was found to be a component of mammalian SWI/SNF-like BAF …

Inositol phosphates are a large and diverse family of signalling molecules. While genetic
studies have discovered important functions for them, the biochemistry behind these roles is …

Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that
have a range of signaling functions. Since the discovery of inositol pyrophosphates in the …

This review assesses the extent and the significance of catalytic versatility shown by several
inositol phosphate kinases: the inositol phosphate multikinase, the reversible Ins (1, 3, 4) P …