Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

[HTML][HTML] METTL3 plays multiple functions in biological processes

S Liu, L Zhuo, J Wang, Q Zhang, Q Li, G Li… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification of mRNAs
in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like …

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

H Song, X Feng, H Zhang, Y Luo, J Huang, M Lin… - Autophagy, 2019 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) mRNA modifications play critical roles in various
biological processes. However, no study addresses the role of m6A in macroautophagy …

The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice

JM Petrosino, SA Hinger, VA Golubeva… - Nature …, 2022 - nature.com
Skeletal muscle serves fundamental roles in organismal health. Gene expression
fluctuations are critical for muscle homeostasis and the response to environmental insults …

[HTML][HTML] Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

Y Qiao, Q Sun, X Chen, L He, D Wang, R Su, Y Xue… - Elife, 2023 - ncbi.nlm.nih.gov
Skeletal muscle stem cells (also known as satellite cells [SCs]) are essential for muscle
regeneration and the regenerative activities of SCs are intrinsically governed by gene …

[HTML][HTML] Regulation of myogenic gene expression

C Vicente-García, JD Hernández-Camacho… - Experimental Cell …, 2022 - Elsevier
Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

METTL3‐Mediated m6A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway

Y Liang, H Han, Q Xiong, C Yang, L Wang… - Stem cells …, 2021 - Wiley Online Library
The Pax7+ muscle stem cells (MuSCs) are essential for skeletal muscle homeostasis and
muscle regeneration upon injury, while the molecular mechanisms underlying muscle stem …

A defined N6-methyladenosine (m6A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions

BJ Gheller, JE Blum, EHH Fong, OV Malysheva… - Cell death …, 2020 - nature.com
Muscle-specific adult stem cells (MuSCs) are required for skeletal muscle regeneration. To
ensure efficient skeletal muscle regeneration after injury, MuSCs must undergo state …

Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis

X Chen, W Hua, X Huang, Y Chen, J Zhang… - Frontiers in …, 2020 - frontiersin.org
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …

lncMGPF is a novel positive regulator of muscle growth and regeneration

W Lv, J Jin, Z Xu, H Luo, Y Guo, X Wang… - Journal of cachexia …, 2020 - Wiley Online Library
Abstract Background Long non‐coding RNAs (lncRNAs) play critical regulatory roles in
diverse biological processes and diseases. While a large number of lncRNAs have been …