Unraveling plant natural chemical diversity for drug discovery purposes

E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Chemodiversity, chemotaxonomy and chemoecology of Amaryllidaceae alkaloids

S Berkov, E Osorio, F Viladomat, J Bastida - The alkaloids: chemistry and …, 2020 - Elsevier
The Amaryllidaceae alkaloids are a distinctive chemotaxonomic feature of the subfamily
Amaryllidoideae of the family Amaryllidaceae, which consists of 59 genera and> 800 …

Chemical derivatization of natural products: Semisynthesis and pharmacological aspects-A decade update

S Majhi, D Das - Tetrahedron, 2021 - Elsevier
Natural products and their semisynthetic derivatives continue to be an important source of
potential drug leads. Natural products and their analogues structures possess the …

Aconitine induces cardiomyocyte damage by mitigating BNIP3‐dependent mitophagy and the TNFα‐NLRP3 signalling axis

F Peng, N Zhang, C Wang, X Wang, W Huang… - Cell …, 2020 - Wiley Online Library
Objectives Aconitine, the natural product extracted from Aconitum species, is widely used for
the treatment of various diseases, including rheumatism, arthritis, bruises, fractures and …

Enantioselective synthesis of isocarbostyril alkaloids and analogs using catalytic dearomative functionalization of benzene

TW Bingham, LW Hernandez, DG Olson… - Journal of the …, 2018 - ACS Publications
Enantioselective total syntheses of the anticancer isocarbostyril alkaloids (+)-7-
deoxypancratistatin,(+)-pancratistatin,(+)-lycoricidine, and (+)-narciclasine are described …

The role of biocatalysis in the asymmetric synthesis of alkaloids–an update

E Cigan, B Eggbauer, JH Schrittwieser, W Kroutil - RSC advances, 2021 - pubs.rsc.org
Alkaloids are a group of natural products with interesting pharmacological properties and a
long history of medicinal application. Their complex molecular structures have fascinated …

Circularly polarized luminescence of natural products lycorine and narciclasine: role of excited-state intramolecular proton-transfer and test of pH sensitivity

G Mazzeo, M Fusè, A Evidente, S Abbate… - Physical Chemistry …, 2023 - pubs.rsc.org
Circularly polarized luminescence (CPL) is increasingly gaining interest not only for its
applicative potentialities but also for providing an understanding of the excited state …

Benefits of unconventional methods in the total synthesis of natural products

T Hudlicky - ACS omega, 2018 - ACS Publications
This article provides a survey of four “unconventional” methods employed in the synthesis of
natural products in the Hudlicky group. The utility of flash vacuum pyrolysis is highlighted by …

Enantioselective Synthesis of Arene cis‐Dihydrodiols from 2‐Pyrones

XW Liang, Y Zhao, XG Si, MM Xu, JH Tan… - Angewandte …, 2019 - Wiley Online Library
An enantioselective chemical synthesis of arene cis‐dihydrodiols has been realized from 2‐
pyrones through sequential ytterbium‐catalyzed asymmetric inverse‐electron‐demand Diels …

Switching from biaryl formation to amidation with convoluted polymeric nickel catalysis

A Sen, RN Dhital, T Sato, A Ohno, YMA Yamada - ACS Catalysis, 2020 - ACS Publications
A stable, reusable, and insoluble poly (4-vinylpyridine) nickel catalyst (P4VP-NiCl2) was
prepared through the molecular convolution of poly (4-vinylpyridine)(P4VP) and nickel …