Interrogating amyloid aggregates using fluorescent probes

A Aliyan, NP Cook, AA Martí - Chemical reviews, 2019 - ACS Publications
Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …

A new generation of NIR‐II probes: lanthanide‐based nanocrystals for bioimaging and biosensing

Y Fan, F Zhang - Advanced Optical Materials, 2019 - Wiley Online Library
Fluorescence‐based imaging in the second near infrared window (NIR‐II, 1000–1700 nm) is
extensively used in both fundamental scientific research and clinical practice, owing to its …

An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques

J Miao, M Miao, Y Jiang, M Zhao, Q Li… - Angewandte Chemie …, 2023 - Wiley Online Library
Fluorescence imaging in the second near‐infrared (NIR‐II) window holds great promise for
in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and …

NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer

P Wang, Y Fan, L Lu, L Liu, L Fan, M Zhao, Y Xie… - Nature …, 2018 - nature.com
Local recurrence is a common cause of treatment failure for patients with solid tumors.
Tumor-specific intraoperative fluorescence imaging may improve staging and debulking …

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease

MR Minter, C Zhang, V Leone, DL Ringus, X Zhang… - Scientific reports, 2016 - nature.com
Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …

Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice

R Ni, Z Chen, XL Deán-Ben, FF Voigt… - Nature Biomedical …, 2022 - nature.com
Deposits of amyloid-β (Aβ) in the brains of rodents can be analysed by invasive intravital
microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the …

Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice

SS Hou, J Yang, JH Lee, Y Kwon… - Nature biomedical …, 2023 - nature.com
Non-invasive methods for the in vivo detection of hallmarks of Alzheimer's disease can
facilitate the study of the progression of the disease in mouse models and may enable its …

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of …

MR Minter, R Hinterleitner, M Meisel, C Zhang… - Scientific reports, 2017 - nature.com
Recent evidence suggests the commensal microbiome regulates host immunity and
influences brain function; findings that have ramifications for neurodegenerative diseases. In …

Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and tau aggregates in Alzheimer's disease

H Rai, S Gupta, S Kumar, J Yang… - Journal of Medicinal …, 2022 - ACS Publications
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …

Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases

P Maiti, GL Dunbar - International journal of molecular sciences, 2018 - mdpi.com
Progressive accumulation of misfolded amyloid proteins in intracellular and extracellular
spaces is one of the principal reasons for synaptic damage and impairment of neuronal …