Interrogating amyloid aggregates using fluorescent probes
Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …
A new generation of NIR‐II probes: lanthanide‐based nanocrystals for bioimaging and biosensing
Fluorescence‐based imaging in the second near infrared window (NIR‐II, 1000–1700 nm) is
extensively used in both fundamental scientific research and clinical practice, owing to its …
extensively used in both fundamental scientific research and clinical practice, owing to its …
An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques
J Miao, M Miao, Y Jiang, M Zhao, Q Li… - Angewandte Chemie …, 2023 - Wiley Online Library
Fluorescence imaging in the second near‐infrared (NIR‐II) window holds great promise for
in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and …
in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and …
NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer
Local recurrence is a common cause of treatment failure for patients with solid tumors.
Tumor-specific intraoperative fluorescence imaging may improve staging and debulking …
Tumor-specific intraoperative fluorescence imaging may improve staging and debulking …
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease
Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …
Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice
Deposits of amyloid-β (Aβ) in the brains of rodents can be analysed by invasive intravital
microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the …
microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the …
Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice
Non-invasive methods for the in vivo detection of hallmarks of Alzheimer's disease can
facilitate the study of the progression of the disease in mouse models and may enable its …
facilitate the study of the progression of the disease in mouse models and may enable its …
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of …
Recent evidence suggests the commensal microbiome regulates host immunity and
influences brain function; findings that have ramifications for neurodegenerative diseases. In …
influences brain function; findings that have ramifications for neurodegenerative diseases. In …
Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and tau aggregates in Alzheimer's disease
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …
Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases
P Maiti, GL Dunbar - International journal of molecular sciences, 2018 - mdpi.com
Progressive accumulation of misfolded amyloid proteins in intracellular and extracellular
spaces is one of the principal reasons for synaptic damage and impairment of neuronal …
spaces is one of the principal reasons for synaptic damage and impairment of neuronal …