Macrophages are traditional innate immune cells that play critical roles in the clearance of
pathogens and the maintenance of tissue homeostasis. Accumulating evidence proves that …

Highlights•Mononuclear phagocyte system (MPS), especially macrophages, must be
selective.•Phagocytosis is not just driven by antibodies on a target.•Phagocytosis is also …

Cancer cells elude anti-tumour immunity through multiple mechanisms, including
upregulated expression of ligands for inhibitory immune checkpoint receptors,. Phagocytosis …

Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by
macrophages and is a promising avenue in anti-cancer therapy. Productive phagocytosis is …

Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and
repair of our bones are formed from bone marrow myeloid progenitor cells by a complex …

Protein-tyrosine phosphatases (PTPs) remove phosphate groups from tyrosine residues,
and thereby propagate or inhibit signal transduction, and hence influence cellular processes …

Implantation of biomaterials in vascularized tissues elicits the sequential engagement of
molecular and cellular elements that constitute the foreign body response. Initial events …

Myocardial infarction (MI) triggers an inflammatory reaction, in which macrophages are of
key importance for tissue repairing. Infiltration and/or migration of macrophages into the …

Epithelial-mesenchymal transition (EMT) is thought to contribute to metastasis and
chemoresistance in patients with hepatocellular carcinoma (HCC), leading to their poor …

Skeletal development and homeostasis in mammals are modulated by finely coordinated
processes of migration, proliferation, differentiation, and death of skeletogenic cells …