Drug repurposing to overcome microbial resistance

J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome

AS McGovern, AS Hamlin… - Australian & New …, 2019 - journals.sagepub.com
Objective: Serotonin reuptake inhibitors are the predominant treatment for major depressive
disorder. In recent years, the diversity of the gut microbiota has emerged to play a significant …

[HTML][HTML] Unravelling the antimicrobial action of antidepressants on gut commensal microbes

Y Ait Chait, W Mottawea, TA Tompkins, R Hammami - Scientific reports, 2020 - nature.com
Over the past decade, there has been increasing evidence highlighting the implication of the
gut microbiota in a variety of brain disorders such as depression, anxiety, and …

[HTML][HTML] Clinical significance of microbiota changes under the influence of psychotropic drugs. An updated narrative review

A Misera, I Łoniewski, J Palma, M Kulaszyńska… - Frontiers in …, 2023 - frontiersin.org
Relationship between drugs and microbiota is bilateral. Proper composition thus function of
microbiota is a key to some medications used in modern medicine. However, there is also …

[HTML][HTML] Repurposing antidepressants and phenothiazine antipsychotics as efflux pump inhibitors in cancer and infectious diseases

B Rácz, G Spengler - Antibiotics, 2023 - mdpi.com
Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and
cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) …

Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review

VS Foletto, TF da Rosa, MB Serafin, A Bottega… - International Journal of …, 2021 - Elsevier
The global spread of microbial resistance coupled with high costs and slow pace in the
discovery of a new antibiotic have made drug repositioning an attractive and promising …

[HTML][HTML] Antimicrobial activity of antidepressants on normal gut microbiota: Results of the in vitro study

G Rukavishnikov, L Leonova, E Kasyanov… - Frontiers in Behavioral …, 2023 - frontiersin.org
Currently, there is little published data on the effects of antidepressants on normal gut
microbiota and the consequences of such effects on treatment outcomes. The aim of the …

[HTML][HTML] Staphylococcus Infection: Relapsing Atopic Dermatitis and Microbial Restoration

J Hulme - Antibiotics, 2023 - mdpi.com
Atopic Dermatitis (AD) skin is susceptible to Staphylococcus aureus (SA) infection,
potentially exposing it to a plethora of toxins and virulent determinants, including Panton …

[HTML][HTML] The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds

A Kiecka, M Szczepanik - Pharmacological Reports, 2022 - Springer
Selective serotonin reuptake inhibitors (SSRIs) are used to treat affective and anxiety
disorders. Antidepressants have also been shown to have antimicrobial and …

Nutritional and therapeutic approaches for protecting human gut microbiota from psychotropic treatments

YA Chait, W Mottawea, TA Tompkins… - Progress in Neuro …, 2021 - Elsevier
Emerging evidence highlighted the essential role played by the microbiota-gut-brain axis in
maintaining human homeostasis, including nutrition, immunity, and metabolism. Much …