[HTML][HTML] Shifting the cancer screening paradigm: the rising potential of blood-based multi-cancer early detection tests
Cancer remains a leading cause of death worldwide, partly owing to late detection which
entails limited and often ineffective therapeutic options. Most cancers lack validated …
entails limited and often ineffective therapeutic options. Most cancers lack validated …
[HTML][HTML] Multi-cancer early detection: the new frontier in cancer early detection
CE Guerra, PV Sharma… - Annual Review of Medicine, 2024 - annualreviews.org
The new generation of cancer early detection tests holds remarkable promise for
revolutionizing and changing the paradigm of cancer early detection. Dozens of cancer early …
revolutionizing and changing the paradigm of cancer early detection. Dozens of cancer early …
[HTML][HTML] Accurate screening for early-stage breast cancer by detection and profiling of circulating tumor cells
T Crook, R Leonard, K Mokbel, A Thompson, M Michell… - Cancers, 2022 - mdpi.com
Simple Summary Detection of breast cancer in the early stages is associated with higher
cure rates and better survival, and also requires fewer intensive treatments. Current breast …
cure rates and better survival, and also requires fewer intensive treatments. Current breast …
Cancer-associated fibroblast subpopulations with diverse and dynamic roles in the tumor microenvironment
T Simon, B Salhia - Molecular Cancer Research, 2022 - AACR
Close interactions between cancer cells and cancer-associated fibroblasts (CAF) have
repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed …
repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed …
Profiling of circulating glial cells for accurate blood‐based diagnosis of glial malignancies
K O'Neill, N Syed, T Crook, S Dubey… - … Journal of Cancer, 2024 - Wiley Online Library
Here, we describe a blood test for the detection of glial malignancies (GLI‐M) based on the
identification of circulating glial cells (CGCs). The test is highly specific for GLI‐M and can …
identification of circulating glial cells (CGCs). The test is highly specific for GLI‐M and can …
[HTML][HTML] Proteomics and its applications in breast cancer
Breast cancer is an individually unique, multi-faceted and chameleonic disease, an eternal
challenge for the new era of high-integrated precision diagnostic and personalized …
challenge for the new era of high-integrated precision diagnostic and personalized …
[HTML][HTML] How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy
Circulating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are
detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC …
detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC …
Sorting technology for circulating tumor cells based on microfluidics
Circulating tumor cells (CTCs) carry reliable clinical information for the diagnosis and
treatment of cancer that is a malignant disease with a high mortality rate. However, the …
treatment of cancer that is a malignant disease with a high mortality rate. However, the …
Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells
S Limaye, S Chowdhury, N Rohatgi, A Ranade… - Cancer …, 2023 - Wiley Online Library
Background The low specificity of serum PSA resulting in the inability to effectively
differentiate prostate cancer from benign prostate conditions is a persistent clinical …
differentiate prostate cancer from benign prostate conditions is a persistent clinical …
Circulating tumor cells as Trojan Horse for understanding, preventing, and treating cancer: a critical appraisal
AFA Mentis, PD Grivas, E Dardiotis, NA Romas… - Cellular and Molecular …, 2020 - Springer
Circulating tumor cells (CTCs) are regarded as harbingers of metastases. Their ability to
predict response to therapy, relapse, and resistance to treatment has proposed their value …
predict response to therapy, relapse, and resistance to treatment has proposed their value …