[HTML][HTML] Shifting the cancer screening paradigm: the rising potential of blood-based multi-cancer early detection tests

T Brito-Rocha, V Constâncio, R Henrique, C Jerónimo - Cells, 2023 - mdpi.com
Cancer remains a leading cause of death worldwide, partly owing to late detection which
entails limited and often ineffective therapeutic options. Most cancers lack validated …

[HTML][HTML] Multi-cancer early detection: the new frontier in cancer early detection

CE Guerra, PV Sharma… - Annual Review of Medicine, 2024 - annualreviews.org
The new generation of cancer early detection tests holds remarkable promise for
revolutionizing and changing the paradigm of cancer early detection. Dozens of cancer early …

[HTML][HTML] Accurate screening for early-stage breast cancer by detection and profiling of circulating tumor cells

T Crook, R Leonard, K Mokbel, A Thompson, M Michell… - Cancers, 2022 - mdpi.com
Simple Summary Detection of breast cancer in the early stages is associated with higher
cure rates and better survival, and also requires fewer intensive treatments. Current breast …

Cancer-associated fibroblast subpopulations with diverse and dynamic roles in the tumor microenvironment

T Simon, B Salhia - Molecular Cancer Research, 2022 - AACR
Close interactions between cancer cells and cancer-associated fibroblasts (CAF) have
repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed …

Profiling of circulating glial cells for accurate blood‐based diagnosis of glial malignancies

K O'Neill, N Syed, T Crook, S Dubey… - … Journal of Cancer, 2024 - Wiley Online Library
Here, we describe a blood test for the detection of glial malignancies (GLI‐M) based on the
identification of circulating glial cells (CGCs). The test is highly specific for GLI‐M and can …

[HTML][HTML] Proteomics and its applications in breast cancer

AN Neagu, D Whitham, E Buonanno… - American journal of …, 2021 - ncbi.nlm.nih.gov
Breast cancer is an individually unique, multi-faceted and chameleonic disease, an eternal
challenge for the new era of high-integrated precision diagnostic and personalized …

[HTML][HTML] How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy

MM Nasr, CC Lynch - Cancer and Metastasis Reviews, 2023 - Springer
Circulating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are
detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC …

Sorting technology for circulating tumor cells based on microfluidics

D Hu, H Liu, Y Tian, Z Li, X Cui - ACS Combinatorial Science, 2020 - ACS Publications
Circulating tumor cells (CTCs) carry reliable clinical information for the diagnosis and
treatment of cancer that is a malignant disease with a high mortality rate. However, the …

Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells

S Limaye, S Chowdhury, N Rohatgi, A Ranade… - Cancer …, 2023 - Wiley Online Library
Background The low specificity of serum PSA resulting in the inability to effectively
differentiate prostate cancer from benign prostate conditions is a persistent clinical …

Circulating tumor cells as Trojan Horse for understanding, preventing, and treating cancer: a critical appraisal

AFA Mentis, PD Grivas, E Dardiotis, NA Romas… - Cellular and Molecular …, 2020 - Springer
Circulating tumor cells (CTCs) are regarded as harbingers of metastases. Their ability to
predict response to therapy, relapse, and resistance to treatment has proposed their value …