Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks
H Yang, S Ren, S Yu, H Pan, T Li, S Ge… - International journal of …, 2020 - mdpi.com
Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …
applications are under development. The programmable nuclease Cas9, directed by a …
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells
DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
How cells ensure correct repair of DNA double-strand breaks
J Her, SF Bunting - Journal of Biological Chemistry, 2018 - ASBMB
DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
Homology-directed repair and the role of BRCA1, BRCA2, and related proteins in genome integrity and cancer
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
Regulation of repair pathway choice at two-ended DNA double-strand breaks
A Shibata - … Research/Fundamental and Molecular Mechanisms of …, 2017 - Elsevier
A DNA double-strand break (DSB) is considered to be a critical DNA lesion because its
misrepair can cause severe mutations, such as deletions or chromosomal translocations …
misrepair can cause severe mutations, such as deletions or chromosomal translocations …
BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation
BRCA1 promotes homologous recombination (HR) by activating DNA-end resection. By
contrast, 53BP1 forms a barrier that inhibits DNA-end resection. Here, we show that BRCA1 …
contrast, 53BP1 forms a barrier that inhibits DNA-end resection. Here, we show that BRCA1 …
Methylation of DNA ligase 1 by G9a/GLP recruits UHRF1 to replicating DNA and regulates DNA methylation
L Ferry, A Fournier, T Tsusaka, G Adelmant, T Shimazu… - Molecular cell, 2017 - cell.com
DNA methylation is an essential epigenetic mark in mammals that has to be re-established
after each round of DNA replication. The protein UHRF1 is essential for this process; it has …
after each round of DNA replication. The protein UHRF1 is essential for this process; it has …
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …
metabolism and cell growth by sensing diverse environmental signals, including amino …
Genome stability and evolution: attempting a holistic view
I Schubert, GTH Vu - Trends in plant science, 2016 - cell.com
The reason why the DNA content, chromosome number and shape, and gene content of
eukaryotic genomes vary independently remains a matter of speculation. The same is true …
eukaryotic genomes vary independently remains a matter of speculation. The same is true …