Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle
and proliferation of both normal and malignant tissues. Dysregulation of this fundamental …

The intracellular location of a protein is crucial to its normal functioning in a cell. Cancer cells
utilize the normal processes of nuclear-cytoplasmic transport through the nuclear pore …

Studies have demonstrated that noncoding RNAs play important roles in various types of
cancer; however, noncoding RNAs derived from regions of genomic alterations have rarely …

The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic
mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack …

Purpose This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy
of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1) …

The key nuclear export protein CRM1/XPO1 may represent a promising novel therapeutic
target in human multiple myeloma (MM). Here we showed that chromosome region …

Chromosomal region maintenance 1 (CRM1) is a nuclear export receptor recognizing
proteins bearing a leucine-rich nuclear export signal. CRM1 is involved in nuclear export of …

Purpose We evaluated the pharmacokinetics (PKs), pharmacodynamics, safety, and efficacy
of selinexor, an oral selective inhibitor of nuclear export compound, in patients with …

This study explored the anti‐leukaemic efficacy of novel irreversible inhibitors of the major
nuclear export receptor, chromosome region maintenance 1 (CRM 1, also termed XPO 1) …

Multiple myeloma (MM) is a malignancy of plasma cells that is typically chronic, and relapse
is common. Current therapeutic strategies include combination and sequential treatments …