Background Articular cartilage defects are a veritable therapeutic problem because
therapeutic options are very scarce. Due to the poor self-regeneration capacity of cartilage …

One of the defining pathological features of Alzheimer disease (AD) is the intraneuronal
accumulation of tau. The tau that forms these accumulations is altered both …

Background The genetic cause of cerebral autosomal recessive arteriopathy with subcortical
infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic …

Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus,
which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature …

Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Many conditions affecting the heart, brain, and even the eyes have their origins in blood
vessel pathology, underscoring the role of vascular regulation. In age-related macular …

Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

The defining features of the widely conserved HtrA (high temperature requirement) family of
serine proteases are the combination of a catalytic protease domain with one or more C …

The HtrA proteases degrade damaged proteins and thus control the quality of proteins and
protect cells against the consequences of various stresses; they also recognize specific …

Age-related macular degeneration (AMD) is the leading cause of permanent, irreversible,
central blindness (scotoma in the central visual field that makes reading and writing …