Cholinergic receptor modulation as a target for preventing dementia in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) in the midbrain …
dopaminergic neurons in the substantia nigra pars compacta (SNpc) in the midbrain …
Striatal cholinergic interneurons: how to elucidate their function in health and disease
Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum
and are believed to play an important role in basal ganglia physiology and pathophysiology …
and are believed to play an important role in basal ganglia physiology and pathophysiology …
Neurotransmitters, cell types, and circuit mechanisms of motor skill learning and clinical applications
W Tian, S Chen - Frontiers in Neurology, 2021 - frontiersin.org
Animals acquire motor skills to better survive and adapt to a changing environment. The
ability to learn novel motor actions without disturbing learned ones is essential to …
ability to learn novel motor actions without disturbing learned ones is essential to …
The interplay between cerebellum and basal ganglia in motor adaptation: A modeling study
Motor adaptation to perturbations is provided by learning mechanisms operating in the
cerebellum and basal ganglia. The cerebellum normally performs motor adaptation through …
cerebellum and basal ganglia. The cerebellum normally performs motor adaptation through …
Dopamine transmission in the tail striatum: Regional variation and contribution of dopamine clearance mechanisms
The striatum can be divided into four anatomically and functionally distinct domains: the
dorsolateral, dorsomedial, ventral and the more recently identified caudolateral (tail) …
dorsolateral, dorsomedial, ventral and the more recently identified caudolateral (tail) …
The critical balance between dopamine D2 receptor and RGS for the sensitive detection of a transient decay in dopamine signal
H Urakubo, S Yagishita, H Kasai… - PLoS computational …, 2021 - journals.plos.org
In behavioral learning, reward-related events are encoded into phasic dopamine (DA)
signals in the brain. In particular, unexpected reward omission leads to a phasic decrease in …
signals in the brain. In particular, unexpected reward omission leads to a phasic decrease in …
A TAN-dopamine interaction mechanism based computational model of basal ganglia in action selection
Q Zhu, F Han, Y Yuan, L Shen - Cognitive Neurodynamics, 2023 - Springer
The basal ganglia (BG) plays a key role in action selection. Physiological experiments have
suggested that the reciprocal interaction between tonically active neurons (TANs) and …
suggested that the reciprocal interaction between tonically active neurons (TANs) and …
A multiscale, systems-level, neuropharmacological model of cortico-basal ganglia system for arm reaching under normal, Parkinsonian, and Levodopa medication …
SS Nair, VR Muddapu… - Frontiers in Computational …, 2022 - frontiersin.org
In order to understand the link between substantia nigra pars compacta (SNc) cell loss and
Parkinson's disease (PD) symptoms, we developed a multiscale computational model that …
Parkinson's disease (PD) symptoms, we developed a multiscale computational model that …
[HTML][HTML] Tonically active neurons in the monkey dorsal striatum signal outcome feedback during trial-and-error search behavior
H Inokawa, N Matsumoto, M Kimura, H Yamada - Neuroscience, 2020 - Elsevier
An animal's choice behavior is shaped by the outcome feedback from selected actions in a
trial-and-error approach. Tonically active neurons (TANs), presumed cholinergic …
trial-and-error approach. Tonically active neurons (TANs), presumed cholinergic …
A spiking computational model for striatal cholinergic interneurons
MG Codianni, JE Rubin - Brain Structure and Function, 2023 - Springer
Cholinergic interneurons in the striatum, also known as tonically active interneurons or
TANs, are thought to have a strong effect on corticostriatal plasticity and on striatal activity …
TANs, are thought to have a strong effect on corticostriatal plasticity and on striatal activity …