MENIN‐mediated regulation of gastrin gene expression and its role in gastrinoma development
UB Elvis‐Offiah, S Duan, JL Merchant - The FASEB Journal, 2023 - Wiley Online Library
Abstract The Multiple Endocrine Neoplasia I (MEN1) locus encodes the protein MENIN,
which functions as a tumor suppressor protein in neuroendocrine tissues. Gastrinomas are …
which functions as a tumor suppressor protein in neuroendocrine tissues. Gastrinomas are …
[HTML][HTML] Deep Learning Techniques to Characterize the RPS28P7 Pseudogene and the Metazoa-SRP Gene as Drug Potential Targets in Pancreatic Cancer …
The molecular explanation about why some pancreatic cancer (PaCa) patients die early and
others die later is poorly understood. This study aimed to discover potential novel markers …
others die later is poorly understood. This study aimed to discover potential novel markers …
[HTML][HTML] Neoplasia endocrina múltiple tipo 1: un abordaje práctico
MPP Salas, DV Peña, KFC Núñez… - …, 2023 - revista-portalesmedicos.com
La neoplasia endocrina múltiple tipo 1 (MEN 1) es un síndrome genético poco común, con
herencia autosómica dominante, caracterizado principalmente por la co aparición de …
herencia autosómica dominante, caracterizado principalmente por la co aparición de …
[HTML][HTML] Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover
S Duan, S Sheriff, UB Elvis-Offiah, BL Witten… - Cancer Research …, 2023 - AACR
Loss of the tumor suppressor protein menin is a critical event underlying the formation of
neuroendocrine tumors (NET) in hormone-expressing tissues including gastrinomas. While …
neuroendocrine tumors (NET) in hormone-expressing tissues including gastrinomas. While …
Follow-up study of a Colombian family with a novel MEN1 variant and rare ACTH-producing pancreatic neuroendocrine carcinoma
JC Riaño-Moreno, AM González-Clavijo… - 2023 - researchsquare.com
Purpose This article reports on a 12-year follow-up of a Colombian family with a novel MEN1
gene variant (c. 698dup, p. Met233IlefsTer4), identified through cascade genetic screening …
gene variant (c. 698dup, p. Met233IlefsTer4), identified through cascade genetic screening …