The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-
fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading …

The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase,
hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons …

B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

The classical perception of adipose tissue as a storage place of fatty acids has been
replaced over the last years by the notion that adipose tissue has a central role in lipid and …

Organisms must adapt to fluctuating nutrient availability to maintain energy homeostasis.
Here, we term the capacity for such adaptation and restoration" metabolic elasticity" and …

The obesity epidemic has focused attention on adipose tissue and the development of fat
cells (ie adipocytes), which is known as adipogenesis. Peroxisome proliferator-activated …

Thiazolidinediones (TZDs) are anti-diabetic drugs that act as insulin sensitizers and are
used in the management of type 2 diabetes mellitus. TZDs, which are ligands for the …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …