Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether
barrier breakdown is sufficient to trigger neurodegenerative disease remains unresolved …

Diabetic retinopathy (DR) is a significant cause of vision loss and a research subject that is
constantly being explored for new mechanisms of damage and potential therapeutic options …

Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-
selective cation channels expressed in different cell types of the central nervous system …

The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP
superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate …

Aqueous humor drainage from the anterior eye determines intraocular pressure (IOP) under
homeostatic and pathological conditions. Swelling of the trabecular meshwork (TM) alters its …

Key points Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that
regulates intraocular pressure through the control of aqueous humour drainage. Its …