Characterisation of a Drosophila model to investigate the contributions of Tau and ApoE in neurodegenerative disease

L Minkley - 2023 - sussex.figshare.com
Neurofibrillary tangles composed of hyperphosphorylated Tau are a key pathological
hallmark of Alzheimer's disease (AD), and aggregated Tau pathology in glia as well as …

Investigating the role of Alzheimer's risk genes PLCγ2 and PLD3 in glial engulfment using drosophila

F Storer - 2022 - orca.cardiff.ac.uk
Microglial dysfunction is likely to play an important role in the pathogenesis of Alzheimer's
disease (AD). Dysregulated glial cells can excessively eliminate neuronal synapses of AD …

Drosophila melanogaster: An Immaculate Model for Glial Research

Pragati, S Tandon, Aqsa, P Aggarwal… - The Biology of Glial Cells …, 2022 - Springer
Although glial cells have been typically regarded as support cells of the neurons, it is
increasingly clear now that they play a critical role (s) in the development, function, and …