In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

The base excision repair (BER) pathway historically has been associated with maintaining
genome integrity by eliminating nucleobases with small chemical modifications. In the past …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat
BRCA-deficient breast, ovarian and prostate cancers. As their efficacy is potentiated by loss …

Base excision repair (BER) is one of several DNA repair pathways found in all three
domains of life. BER counters the mutagenic and cytotoxic effects of damage that occurs …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Endogenous and exogenous reactive species cause oxidatively induced DNA damage in
living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or …

5-Formyl-dC (fdC) and 5-carboxy-dC (cadC) are newly discovered bases in the mammalian
genome that are supposed to be substrates for base excision repair (BER) in the framework …

We have purified ledodin, a cytotoxic 22‐kDa protein from shiitake mushroom (Lentinula
edodes) consisting of a 197 amino acid chain. Ledodin possessed N‐glycosylase activity on …