GMP synthetase: allostery, structure, and function
L Ballut, S Violot, S Kumar, N Aghajari, H Balaram - Biomolecules, 2023 - mdpi.com
Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the
generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and …
generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and …
Mechanistic insights into the functioning of a two-subunit GMP synthetase, an allosterically regulated, ammonia channeling enzyme
S Shivakumaraswamy, S Kumar, A Bellur… - Biochemistry, 2022 - ACS Publications
Guanosine 5′-monophosphate (GMP) synthetases, enzymes that catalyze the conversion
of xanthosine 5′-monophosphate (XMP) to GMP, are composed of two different catalytic …
of xanthosine 5′-monophosphate (XMP) to GMP, are composed of two different catalytic …
Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase
Protein ageing is often mediated by the formation of succinimide intermediates. These short-
lived intermediates derive from asparaginyl deamidation and aspartyl dehydration and are …
lived intermediates derive from asparaginyl deamidation and aspartyl dehydration and are …
Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase
JC Oliver, R Gudihal, JW Burgner, AM Pedley… - Archives of biochemistry …, 2014 - Elsevier
GMP synthetase is the glutamine amidotransferase that catalyzes the final step in the
guanylate branch of de novo purine biosynthesis. Conformational changes are required to …
guanylate branch of de novo purine biosynthesis. Conformational changes are required to …
Helices on Interdomain Interface Couple Catalysis in the ATPPase Domain with Allostery in Plasmodium falciparum GMP Synthetase
S Shivakumaraswamy, N Pandey, L Ballut… - …, 2020 - Wiley Online Library
GMP synthetase catalyses the conversion of XMP to GMP through a series of reactions that
include hydrolysis of Gln to generate ammonia in the glutamine amidotransferase (GATase) …
include hydrolysis of Gln to generate ammonia in the glutamine amidotransferase (GATase) …
New insight into the architecture of oxy‐anion pocket in unliganded conformation of GAT domains: A MD‐simulation study
HR Bairagya, M Bansal - Proteins: Structure, Function, and …, 2016 - Wiley Online Library
ABSTRACT Human Guanine Monophosphate Synthetase (hGMPS) converts XMP to GMP,
and acts as a bifunctional enzyme with N‐terminal “glutaminase”(GAT) and C‐terminal …
and acts as a bifunctional enzyme with N‐terminal “glutaminase”(GAT) and C‐terminal …
Mechanistic insights into the functioning of GMP synthetase: a two-subunit, allosterically regulated, ammonia tunnelling enzyme
S Shivakumaraswamy, S Kumar, A Bellur, SD Polisetty… - bioRxiv, 2022 - biorxiv.org
Abstract Guanosine 5'-monophosphate (GMP) synthetases, enzymes that catalyze the
conversion of xanthosine 5'-monophosphate (XMP) to GMP are comprised of two different …
conversion of xanthosine 5'-monophosphate (XMP) to GMP are comprised of two different …