Multiscale modeling has a long history of use in structural biology, as computational
biologists strive to overcome the time-and length-scale limits of atomistic molecular …

Following a review of multiscale simulation methodology, and previous examples of
multiscale models from food science, we present our multiscale simulation framework MULTI …

Abstract We present the Multiscale Coupling Library and Environment: MUSCLE 2. This
multiscale component-based execution environment has a simple to use Java, C++, C …

Inherently complex problems from many scientific disciplines require a multiscale modeling
approach. Yet its practical contents remain unclear and inconsistent. Moreover, multiscale …

Immunological studies frequently analyze individual components (eg, signaling pathways) of
immune systems in a reductionist manner. In contrast, systems immunology aims to give a …

We present a global overview of the methodology developed within the MAPPER European
project to design, implement and run a multiscale simulation on a distributed …

We introduce a software tool to simulate multiscale models: the Multiscale Coupling Library
and Environment 2 (MUSCLE 2). MUSCLE 2 is a component-based modeling tool inspired …

A family of semi-intrusive forward uncertainty propagation (UP) methods for multiscale
models is introduced. The methods are semi-intrusive in the sense that inspection of the …

In several disciplines, a multiscale approach is being used to model complex natural
processes yet a principled background to multiscale modeling is not clear. Additionally …

In this paper, the sensitivity analysis of a single scale model is employed in order to reduce
the input dimensionality of the related multiscale model, in this way, improving the efficiency …