Numerous lines of evidence indicate that chronic inflammation plays a major role in the
development of various neurodegenerative diseases, including Alzheimer's disease …

Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

Glioblastoma (GBM) is the most common primary malignant intracranial tumor. Due to its
high morbidity, high mortality, high recurrence rate, and low cure rate, it has brought great …

The edible and medicinal plants (EMPs) are becoming an abundant source for cancer
prevention and treatment since the natural and healthy trend for modern human beings …

Angelica species have been traditionally used for their medicinal properties. Recent studies
have suggested their potential use as anticancer agents, making them an area of interest for …

NR4A1 (Nur77) belongs together with NR4A2 (Nurr1) and NR4A3 (NOR-1) to the nuclear
orphan receptors of the NR4A-family. Their activation is generally short lived, the cellular …

The orphan nuclear receptor NR4A1/Nur77/TR3/NGFIB acts primarily as a transcription
factor to regulate the expression of multiple genes. However, increasing research attention …

The transcription factor Nur77 belongs to the NR4A subfamily of nuclear hormone receptors.
It features an atypical ligand-binding site that precludes canonical ligand binding, leading to …

Objectives: For reasons of provision of highly‐specific surface area and three‐dimensional
culture, microcarrier culture (MC) has garnered great interest for its potential to expand …

Although butylidenephthalide (BP) is an efficient anticancer drug, its poor bioavailability
renders it ineffective for treating drug-resistant brain tumors. However, this problem is …