Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD
Z Zhang, G Ji, M Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide, affected by
both genetics and environment. Type 2 diabetes (T2D) stands as an independent …
both genetics and environment. Type 2 diabetes (T2D) stands as an independent …
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits
Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a
regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide …
regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide …
Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease
P Yan, L Zhang, C Yang, W Zhang, Y Wang… - Frontiers in …, 2024 - frontiersin.org
Background The relationship between type 2 diabetes mellitus (T2DM) and gallstone
disease (GSD) have been incompletely understood. We aimed to investigate their …
disease (GSD) have been incompletely understood. We aimed to investigate their …
Interplay of Mediterranean-diet adherence, genetic factors, and metabolic dysfunction-associated steatotic liver disease risk in Korea
Backgrounds Metabolic dysfunction-associated steatotic liver disease (MASLD) has gained
attention owing to its severe complications. This study aimed to explore the interaction …
attention owing to its severe complications. This study aimed to explore the interaction …
[HTML][HTML] Compromised chronic efficacy of a Glucokinase Activator AZD1656 in mouse models for common human GCKR variants
Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for
type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy …
type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy …
Genetic predisposition to metabolic dysfunction-associated fatty liver disease
OE Abaturov, AO Nikulina - CHILDS HEALTH, 2024 - childshealth.zaslavsky.com.ua
The literature review highlights the issue of genetic risk factors associated with the
development of metabolic dysfunction-associated fatty liver disease. Human genetic …
development of metabolic dysfunction-associated fatty liver disease. Human genetic …
[PDF][PDF] Генетична схільність до метаболічно асоційованої жирової хвороби печінки
ОЄ Абатуров, АО Нікуліна - Здоров'я дитини …, 2024 - childshealth.zaslavsky.com.ua
Літературний огляд присвячений висвітленню питання щодо генетичних факторів
ризику, що мають зв'язок з розвитком метаболічно асоційованої жирової хвороби …
ризику, що мають зв'язок з розвитком метаболічно асоційованої жирової хвороби …