A decade of progress in tissue engineering
A Khademhosseini, R Langer - Nature protocols, 2016 - nature.com
Tremendous progress has been achieved in the field of tissue engineering in the past
decade. Several major challenges laid down 10 years ago, have been studied, including …
decade. Several major challenges laid down 10 years ago, have been studied, including …
Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis
Q Liu, H Zhang, X Jiang, C Qian, Z Liu, D Luo - Molecular cancer, 2017 - Springer
Metastasis has intrigued researchers for more than 100 years. Despite the development of
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …
technologies and therapeutic strategies, metastasis is still the major cause of cancer-related …
Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models
designed to recapitulate the important biological and physiological parameters of their in …
designed to recapitulate the important biological and physiological parameters of their in …
[HTML][HTML] Tissue engineering by decellularization and 3D bioprinting
Discarded human donor organs have been shown to provide decellularized extracellular
matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell …
matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell …
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies
Investigation of the pharmacokinetics (PK) of a compound is of significant importance during
the early stages of drug development, and therefore several in vitro systems are routinely …
the early stages of drug development, and therefore several in vitro systems are routinely …
[HTML][HTML] Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling
N Chaicharoenaudomrung, P Kunhorm… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Abstract Three-dimensional (3D) culture systems are becoming increasingly popular due to
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …
A human liver microphysiology platform for investigating physiology, drug safety, and disease models
LA Vernetti, N Senutovitch, R Boltz… - Experimental …, 2016 - journals.sagepub.com
This paper describes the development and characterization of a microphysiology platform
for drug safety and efficacy in liver models of disease that includes a human, 3D …
for drug safety and efficacy in liver models of disease that includes a human, 3D …
Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue
We have developed an expandable modular body-on-a-chip system that allows for a plug-
and-play approach with several in vitro tissues. The design consists of single-organ chips …
and-play approach with several in vitro tissues. The design consists of single-organ chips …
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
C Pirazzi, M Adiels, MA Burza, RM Mancina… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: The robust association between non-alcoholic fatty liver disease
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated …
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated …
Comprehensive evaluation of organotypic and microphysiological liver models for prediction of drug-induced liver injury
Y Zhou, JX Shen, VM Lauschke - Frontiers in pharmacology, 2019 - frontiersin.org
Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …
constitutes one of the most important reasons for the termination of promising drug …