The proteasome degrades most cellular proteins in a controlled and tightly regulated
manner and thereby controls many processes, including cell cycle, transcription, signalling …

The ubiquitin–proteasome system (UPS) is the primary selective degradation system in the
nuclei and cytoplasm of eukaryotic cells, required for the turnover of myriad soluble proteins …

The proteasome is the major ATP-dependent protease in eukaryotic cells, but limited
structural information restricts a mechanistic understanding of its activities. The proteasome …

The 26S proteasome is at the executive end of the ubiquitin-proteasome pathway for the
controlled degradation of intracellular proteins. While the structure of its 20S core particle …

The eukaryotic ubiquitin-proteasome system is responsible for most aspects of regulatory
and quality-control protein degradation in cells. Its substrates, which are usually modified by …

The 26S proteasome operates at the executive end of the ubiquitin-proteasome pathway.
Here, we present a cryo-EM structure of the Saccharomyces cerevisiae 26S proteasome at a …

The proteasome refers to a collection of complexes centered on the 20S proteasome core
particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior …

The 26S proteasome is a large multiprotein complex involved in the regulated degradation
of ubiquitinated proteins in the cell. The 26S proteasome has been shown to control an …

Proteasomes execute the degradation of most cellular proteins. Although the 20S core
particle (CP) has been studied in great detail, the structure of the 19S regulatory particle …

The proteasome has a paramount role in eukaryotic cell regulation. It consists of a
proteolytic core particle (CP) bound to one or two regulatory particles (RPs). Each RP is …