The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: multiple sclerosis as a model

K Hoffman, Z Brownell, WJ Doyle… - Journal of autoimmunity, 2023 - Elsevier
The gut-associated lymphoid tissue is a primary activation site for immune responses to
infection and immunomodulation. Experimental evidence using animal disease models …

An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases

WD Xu, DC Wang, M Zhao, AF Huang - Frontiers in Immunology, 2024 - frontiersin.org
Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at
chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of …

Multiple Sclerosis: Diagnosis, Management, and Future Opportunities

E Maida, L Lavorgna - Journal of Clinical Medicine, 2023 - mdpi.com
Multiple sclerosis (MS) is one of the most common inflammatory neurological diseases
which leads to a highly heterogeneous set of symptoms and signs due to the differential …

[HTML][HTML] Interleukin-27 and Autoimmune Disorders: A Compressive Review of Immunological Functions

E Yazdanpanah, A Pazoki, S Dadfar, MH Nemati… - Biomolecules, 2024 - mdpi.com
Autoimmune disorders (ADs) pose significant health and economic burdens globally,
characterized by the body's immune system mistakenly attacking its own tissues. While the …

[HTML][HTML] Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations

L Ciumărnean, OF Sârb, NC Drăghici… - International Journal of …, 2024 - mdpi.com
Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation,
demyelination, and neurodegeneration within the central nervous system. Brain plasticity …

A Pilot Study for Drug-Resistant Tuberculosis Disease Patients Suggests that A964G (rs153109)—Interleukin 27 may be Protective

IM Badamasi, AA Yusuf, IS Abubakar… - Nigerian Journal of …, 2024 - journals.lww.com
Materials and Methods: Two hundred consenting volunteers and drug-resistant tuberculosis
(DR-TB) patients had their blood samples amplified for the A964G (rs153109) gene. The …

Interleukins (IL-23 and IL-27) serum levels: Relationships with gene polymorphisms and disease patterns in multiple sclerosis patients under treatment with interferon …

IS Barac, V Văcăraș, M Iancu, DF Mureșanu… - Heliyon, 2023 - cell.com
Abstract Background interleukin 23 (IL-23) is an important factor involved in the survival and
proliferation of T helper 17 cells (Th17), known for their implication in multiple sclerosis (MS) …

Impact of Genetic Polymorphisms in the Interleukin-18 and Interleukin-21 Genes on the Risk and Clinical Outcomes of Multiple Sclerosis

NM Bakr, NA Hashim, MA El-Eshmawy, HA Eldin - 2024 - researchsquare.com
To study the association between IL-18-137G/C (rs187238) and IL-21-1472G/T (rs2055979)
single nucleotide polymorphisms (SNPs) with the risk of MS, the disease progression, as …

[PDF][PDF] Obesity Control and Nutraceuticals in the Aid of Brain Plasticity in Multiple Sclerosis Patients

OH Orasan, CV Vlad, IM Vlad, T Alexescu, I Para… - 2024 - preprints.org
Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation,
demyelination, and neurodegeneration within the central nervous system. Brain plasticity …

IL-27 rs153109 Polymorphisms and serum level as prognostic risk factor to relapse and resistance in adult patients with Acute Lymphoblastic Leukemia (ALL).

ZK Abdul-Hussein, IA Al-Tamemi - Onkologia i Radioterapia, 2023 - search.ebscohost.com
Abstract Background: Acute Lymphoblastic Leukemia (ALL) is a malignant transformation
and proliferation of lymphoid progenitor B cell (BCPALL) or T cell (T-ALL) origin that invade …