Metabolic contribution and cerebral blood flow regulation by astrocytes in the neurovascular unit

S Takahashi - Cells, 2022 - mdpi.com
The neurovascular unit (NVU) is a conceptual framework that has been proposed to better
explain the relationships between the neural cells and blood vessels in the human brain …

Human and mouse cortical astrocytes: a comparative view from development to morphological and functional characterization

E Degl'Innocenti, MT Dell'Anno - Frontiers in Neuroanatomy, 2023 - frontiersin.org
The vision of astroglia as a bare scaffold to neuronal circuitry has been largely overturned.
Astrocytes exert a neurotrophic function, but also take active part in supporting synaptic …

Astrocytes in post-traumatic stress disorder

B Li, D Zhang, A Verkhratsky - Neuroscience Bulletin, 2022 - Springer
Although posttraumatic stress disorder (PTSD) is on the rise, traumatic events and their
consequences are often hidden or minimized by patients for reasons linked to PTSD itself …

Astroglial connexin 43-mediated gap junctions and hemichannels: potential antidepressant mechanisms and the link to neuroinflammation

L Lei, YT Wang, D Hu, C Gai, Y Zhang - Cellular and Molecular …, 2023 - Springer
Major depression disorder (MDD) is a neuropsychiatric disorder associated with a high
suicide rate and a higher disability rate than any other disease. Evidence suggests that the …

Neurotransmitters in type 2 diabetes and the control of systemic and central energy balance

A Al-Sayyar, MM Hammad, MR Williams, M Al-Onaizi… - Metabolites, 2023 - mdpi.com
Efficient signal transduction is important in maintaining the function of the nervous system
across tissues. An intact neurotransmission process can regulate energy balance through …

Boswellic acid and apigenin alleviate methotrexate-provoked renal and hippocampal alterations in rats: Targeting autophagy, NOD-2/NF-κB/NLRP3, and connexin-43

SA Abd El-Aal, SM El-Sayyad, AA El-Gazar… - International …, 2024 - Elsevier
The neuronal and renal deteriorations observed in patients exposed to methotrexate (MTX)
therapy highlight the need for medical interventions to counteract these complications …

Uptake of biotinylated spermine in astrocytes: effect of Cx43 siRNA, HIV-tat protein and polyamine transport inhibitor on polyamine uptake

CJ Malpica-Nieves, Y Rivera, DE Rivera-Aponte… - Biomolecules, 2021 - mdpi.com
Polyamines (PAs) are polycationic biomolecules containing multiple amino groups. Patients
with HIV-associated neurocognitive disorder (HAND) have high concentrations of the …

Perspective and Therapeutic Potential of the Noncoding RNA–Connexin Axis

X Li, Z Wang, N Chen - International Journal of Molecular Sciences, 2024 - mdpi.com
Noncoding RNAs (ncRNAs) are a class of nucleotide sequences that cannot be translated
into peptides. ncRNAs can function post-transcriptionally by splicing complementary …

Modeling and analysis of voltage gating of gap junction channels at a single-channel level

M Snipas, L Gudaitis, L Kraujaliene, T Kraujalis… - Biophysical journal, 2023 - cell.com
The advancement of single-channel-level recording via the patch-clamp technique has
provided a powerful means of assessing the detailed behaviors of various types of ion …

A fatal alliance: Glial connexins, myelin pathology and mental disorders

A Zlomuzica, L Plank, I Kodzaga, E Dere - Journal of Psychiatric Research, 2023 - Elsevier
Mature oligodendrocytes are myelin forming glial cells which are responsible for myelination
of neuronal axons in the white matter of the central nervous system. Myelin pathology is a …