Many DNA-processing enzymes have been shown to contain a [4Fe4S] cluster, a common
redox cofactor in biology. Using DNA electrochemistry, we find that binding of the DNA …

Abstract The Base Excision Repair (BER) pathway is a highly conserved DNA repair system
targeting subtle chemical base modifications that arise from oxidation, deamination and …

The stacked aromatic base pairs within the DNA double helix facilitate charge transport
down its length in the absence of lesions, mismatches, and other stacking perturbations …

MUTYH is a base-excision repair glycosylase that removes adenine opposite 8-oxoguanine
(OG). Variants of MUTYH defective in functional activity lead to MUTYH-associated …

First-principles calculations of charge transfer in DNA molecules are computationally
expensive given that conducting charge carriers interact with intra-and intermolecular atomic …

DNA damaging agents are a mainstay of standard chemotherapy for ovarian cancer.
Unfortunately, resistance to such DNA damaging agents frequently develops, often due to …

Recent advances have led to numerous landmark discoveries of [4Fe4S] clusters
coordinated by essential enzymes in repair, replication, and transcription across all domains …

Eukaryotic DNA primases contain a [4Fe4S] cluster in the C-terminal domain of the p58
subunit (p58C) that affects substrate affinity but is not required for catalysis. We show that, in …

Translation–protein synthesis at the ribonucleic acid (RNA) based molecular machine, the
ribosome,–proceeds in a similar manner in all life forms. However, despite several decades …

Background Germline pathogenic variants are estimated to affect 3–5% of patients with
renal cell carcinoma (RCC). The identification of patients with hereditary RCC is important …