PI3K/AKT/mTOR signaling pathway in breast cancer: from molecular landscape to clinical aspects
Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …
death through malignancies among women in developed countries. Population …
RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
F Xu, L Na, Y Li, L Chen - Cell & bioscience, 2020 - Springer
Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of
signal transduction and biological processes such as cell proliferation, apoptosis …
signal transduction and biological processes such as cell proliferation, apoptosis …
Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients
Several mutations that cause Parkinson's disease (PD) have been identified over the past
decade. These account for 15–25% of PD cases; the rest of the cases are considered …
decade. These account for 15–25% of PD cases; the rest of the cases are considered …
Control of the eIF4E activity: structural insights and pharmacological implications
The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …
translation has been clearly assessed in the last decades. eIF4E function is essential for …
SNARE regulatory proteins in synaptic vesicle fusion and recycling
CW Sauvola, JT Littleton - Frontiers in molecular neuroscience, 2021 - frontiersin.org
Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by
the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family …
the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family …
Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in
neurons it regulates synaptic transmission, which is thought to be a major mechanism …
neurons it regulates synaptic transmission, which is thought to be a major mechanism …
AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections
Q He, J Du, L Wei, Z Zhao - PLoS Genetics, 2020 - journals.plos.org
Starvation caused by adverse feeding stresses or food shortages has been reported to result
in sleep loss in animals. However, how the starvation signal interacts with the central …
in sleep loss in animals. However, how the starvation signal interacts with the central …
Juvenile hormone acts through FoxO to promote Cdc2 and Orc5 transcription for polyploidy-dependent vitellogenesis
Z Wu, Q He, B Zeng, H Zhou, S Zhou - Development, 2020 - journals.biologists.com
Vitellogenin (Vg) is a prerequisite for egg production and embryonic development after
ovipositioning in oviparous animals. In many insects, juvenile hormone (JH) promotes fat …
ovipositioning in oviparous animals. In many insects, juvenile hormone (JH) promotes fat …
Keeping neurons young and foxy: FoxOs promote neuronal plasticity
CN McLaughlin, HT Broihier - Trends in Genetics, 2018 - cell.com
Any adult who has tried to take up the piano or learn a new language is faced with the
sobering realization that acquiring such skills is more challenging as an adult than as a …
sobering realization that acquiring such skills is more challenging as an adult than as a …
RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development
ABSTRACT Both mRNA-binding Fragile X mental retardation protein (FMRP; Fmr1) and
mRNA-binding Staufen regulate synaptic bouton formation and glutamate receptor (GluR) …
mRNA-binding Staufen regulate synaptic bouton formation and glutamate receptor (GluR) …