Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

DNA damage is a key factor both in the evolution and treatment of cancer. Genomic
instability is a common feature of cancer cells, fuelling accumulation of oncogenic mutations …

Inflammatory gene expression following genotoxic cancer therapy is well documented, yet
the events underlying its induction remain poorly understood. Inflammatory cytokines modify …

Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …

▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …

All life on earth must cope with constant exposure to DNA-damaging agents such as the
Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow …

Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure
to ionizing radiation. Although repair mechanisms such as homologous recombination and …

The serine/threonine protein kinase ATM signals to cell cycle and DNA repair components
by phosphorylating downstream targets such as p53, CHK2, NBS1, and BRCA1. Mutation of …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

The hereditary disorder ataxia telangiectasia (AT) is associated with striking cellular
radiosensitivity that cannot be attributed to the characterized cell cycle checkpoint defects …