Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …

In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

Abnormal aggregation of α-synuclein is thought to be one of core pathogenic factors in PD.
Ca2+ can bind to the C-terminus of α-synuclein, regulate the secretion of α-synuclein, and …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Endoplasmic reticulum (ER)–mitochondria contact sites are critical structures for cellular
function. They are implicated in a plethora of cellular processes, including Ca2+ signalling …

Mitochondria-ER contact sites (MERCS) are known to underpin many important cellular
homoeostatic functions, including mitochondrial quality control, lipid metabolism, calcium …

The brain is highly dependent on mitochondrial energy metabolism. As a result,
mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases …

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …

The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Organelles cooperate with each other to control cellular homeostasis and cell functions by
forming close connections through membrane contact sites. Important contacts are present …