Mitochondrial heterogeneity and homeostasis through the lens of a neuron
G Pekkurnaz, X Wang - Nature metabolism, 2022 - nature.com
Mitochondria are vital organelles with distinct morphological features and functional
properties. The dynamic network of mitochondria undergoes structural and functional …
properties. The dynamic network of mitochondria undergoes structural and functional …
Mitochondrial dynamics in health and disease
In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …
Calcium homeostasis in Parkinson's disease: from pathology to treatment
J Zhang, Q Shen, Y Ma, L Liu, W Jia, L Chen… - Neuroscience Bulletin, 2022 - Springer
Abnormal aggregation of α-synuclein is thought to be one of core pathogenic factors in PD.
Ca2+ can bind to the C-terminus of α-synuclein, regulate the secretion of α-synuclein, and …
Ca2+ can bind to the C-terminus of α-synuclein, regulate the secretion of α-synuclein, and …
Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases
A Markovinovic, J Greig… - Journal of Cell …, 2022 - journals.biologists.com
Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson's Disease
Endoplasmic reticulum (ER)–mitochondria contact sites are critical structures for cellular
function. They are implicated in a plethora of cellular processes, including Ca2+ signalling …
function. They are implicated in a plethora of cellular processes, including Ca2+ signalling …
ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms
EL Wilson, E Metzakopian - Cell Death & Differentiation, 2021 - nature.com
Mitochondria-ER contact sites (MERCS) are known to underpin many important cellular
homoeostatic functions, including mitochondrial quality control, lipid metabolism, calcium …
homoeostatic functions, including mitochondrial quality control, lipid metabolism, calcium …
Neurological disorders and mitochondria
JV Cabral-Costa, AJ Kowaltowski - Molecular aspects of medicine, 2020 - Elsevier
The brain is highly dependent on mitochondrial energy metabolism. As a result,
mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases …
mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases …
[HTML][HTML] Maintaining social contacts: The physiological relevance of organelle interactions
BSC Silva, L DiGiovanni, R Kumar… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …
Microtubule acetylation dyshomeostasis in Parkinson's disease
P Naren, KS Samim, KP Tryphena, LK Vora… - Translational …, 2023 - Springer
The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …
Balancing ER-mitochondrial Ca2+ fluxes in health and disease
J Loncke, A Kaasik, I Bezprozvanny, JB Parys… - Trends in cell …, 2021 - cell.com
Organelles cooperate with each other to control cellular homeostasis and cell functions by
forming close connections through membrane contact sites. Important contacts are present …
forming close connections through membrane contact sites. Important contacts are present …