RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …

Bone repair is a self-healing process. However, critical-sized bone defects need bone
augmentation where bone tissue engineering plays vital role. Bone tissue Engineering …

Drug delivery systems composed of osteogenic substances and biological materials are of
great significance in enhancing bone regeneration, and appropriate biological carriers are …

MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate
posttranscriptional regulation. Based on the level of sequence complementarity, miRNAs …

The treatment of bone defects has plagued clinicians. Exosomes, the naturally secreted
nanovesicles by cells, exhibit great potential in bone defect regeneration to realize cell-free …

Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …

In situ forming implants, defined as liquid formulations that generate solid or semisolid
depots following administration, have shown a range of advantages in drug delivery. This …

Injectable in situ thermosensitive hydrogels have potential applications in tissue engineering
and drug delivery. The hydrogel formulations exist as aqueous solutions at room …