New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Natural killer (NK) cells play critical roles in protection against hematological malignancies
but can acquire a dysfunctional state, which limits antitumor immunity. However, the …

Quorum sensing is a molecular signaling-based communication mechanism in prokaryotes.
In the basic mode, signaling molecules released by certain bacteria are sensed by …

Cell-based therapy (CBT) is a revolutionary approach for curing a variety of degenerative
diseases. Stem cell-based regenerative medicine is a novel strategy for treating tissue …

We previously demonstrated that a high-fat diet (HFD) consumption can cause not only
peripheral insulin resistance, but also neuronal insulin resistance. Moreover, the …

Excessive expansion of adipocytes can have unhealthy consequences as excess free fatty
acids enter other tissues and cause ectopic fat deposition by resynthesizing triglycerides …

Ulcerative colitis (UC) is featured with relapsing inflammation in the colon, where
macrophages are recruited and polarized locally into M1 type to drive further inflammation …

Thiazolidinedione (TZD) class of peroxisome proliferator receptor gamma (PPAR-γ) agonists
display neuroprotective effects in experimental Parkinson's disease (PD) models. Neurons …

Aldosterone (Aldo) causes podocyte damage by an unknown mechanism. We examined the
role of mitochondrial dysfunction (MtD) in Aldo-treated podocytes in vitro and in vivo …