Social determinants of health (SDoH) may impact outcomes in sickle cell disease (SCD). We
conducted a comprehensive literature review of five electronic databases to elucidate the …

To address the global burden of sickle cell disease (SCD) and the need for novel therapies,
the American Society of Hematology partnered with the US Food and Drug Administration to …

Description: In May 2022, leadership within the US Department of Veterans Affairs (VA) and
US Department of Defense (DoD) approved a joint clinical practice guideline for the use of …

Purpose Patients with sickle cell disease (SCD) may experience sickle cell-related pain
crises, also referred to as vaso-occlusive crises (VOCs), which are a substantial cause of …

Sickle cell disease (SCD) is a highly complex inherited disorder of hemoglobin structure.
Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in …

A myriad of studies prove that the American health care system is failing, falling short on
basic dimensions of quality, outcomes, cost, and equity. As proof of this, since 2010, US life …

Pain conditions are among the leading causes of global disability, impacting on global
healthcare utilization (HCU). Health seeking behavior might be influenced by cognitive and …

Background: Sickle-cell disease (SCD) causes significant morbidity, premature mortality,
and high disease burden, resulting in frequent health care use. Comanagement may …

Sickle cell disease is a uniquely complex painful disease, with lifelong episodes of
unpredictable acute pain and superimposed chronic pain in adulthood. Both painful crises …

Abstract Background Adverse childhood experiences (ACEs) are linked to poor health
outcomes; however, the relationship between ACEs and health outcomes among children …