Molecular mechanisms of T cell co-stimulation and co-inhibition
Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they
determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of …
determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of …
The pharmacology of second-generation chimeric antigen receptors
SJC Van Der Stegen, M Hamieh… - Nature reviews Drug …, 2015 - nature.com
Second-generation chimeric antigen receptors (CARs) retarget and reprogramme T cells to
augment their antitumour efficacy. The combined activating and co-stimulatory domains …
augment their antitumour efficacy. The combined activating and co-stimulatory domains …
RCSB Protein Data Bank: Sustaining a living digital data resource that enables breakthroughs in scientific research and biomedical education
Abstract The Protein Data Bank (PDB) is one of two archival resources for experimental data
central to biomedical research and education worldwide (the other key Primary Data Archive …
central to biomedical research and education worldwide (the other key Primary Data Archive …
Clinical experience with CTLA-4 blockade for cancer immunotherapy: From the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules …
The immune checkpoint cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is an
inhibitory regulator of T-cell mediated responses that has been investigated as target of …
inhibitory regulator of T-cell mediated responses that has been investigated as target of …
Strategies to address chimeric antigen receptor tonic signaling
A Ajina, J Maher - Molecular cancer therapeutics, 2018 - AACR
Adoptive cell transfer using chimeric antigen receptors (CAR) has emerged as one of the
most promising new therapeutic modalities for patients with relapsed or refractory B-cell …
most promising new therapeutic modalities for patients with relapsed or refractory B-cell …
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity
The immune system ensures optimum T-effector (Teff) immune responses against invading
microbes and tumor antigens while preventing inappropriate autoimmune responses …
microbes and tumor antigens while preventing inappropriate autoimmune responses …
[HTML][HTML] Mechanisms of costimulation
AH Sharpe - Immunological reviews, 2009 - ncbi.nlm.nih.gov
The immune system has the remarkable ability to defend against a diversity of microbial
pathogens, yet not respond to self. The discovery of the T-cell antigen receptor (TCR) …
pathogens, yet not respond to self. The discovery of the T-cell antigen receptor (TCR) …
A review of pharmacological and pharmacokinetic properties of Forsythiaside A
L Gong, C Wang, H Zhou, C Ma, Y Zhang… - Pharmacological …, 2021 - Elsevier
Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Forsythiae Fructus, the dried …
and has attracted increasing attention for clinical applications. Forsythiae Fructus, the dried …
Human antibodies to PD-1
NJ Papadopoulos, AJ Murphy, G Thurston… - US Patent …, 2018 - Google Patents
The present invention provides antibodies that bind to the T-cell co-inhibitor programmed
death-1 (PD-1) protein, and methods of use. In various embodiments of the invention, the …
death-1 (PD-1) protein, and methods of use. In various embodiments of the invention, the …