Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …

Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding
proteins that organize the actin cytoskeleton and maintain extracellular matrix connections …

Autophagy is a conserved and tightly regulated intracellular quality control pathway. ULK is
a key kinase in autophagy initiation, but whether ULK kinase activity also participates in the …

Filamins (FLNs) are large dimeric actin-binding proteins that regulate actin cytoskeleton
remodeling. In addition, FLNs serve as scaffolds for signaling proteins, such as tyrosine …

Changes in cell morphology and the physical forces that occur during migration are
generated by a dynamic filamentous actin cytoskeleton. The ADP-ribosylation factor–like 4C …

Filamins are large proteins that cross-link actin filaments and connect to other cellular
components. The C-terminal rod 2 region of FLNa (filamin A) mediates dimerization and …

The sarcomere, the fundamental unit of muscle contraction, contains some extraordinarily
large polypeptides (0.6–3 MDa). Most of these proteins belong to the titin family, which was …

The blood-testis barrier (BTB) is an important ultrastructure in the testis. A delay in its
assembly during postnatal development leads to meiotic arrest. Also, a disruption of the BTB …

Simple Summary Rho GDP dissociation inhibitor 2 (RhoGDI2), a regulator of Rho family
GTPase, has been known to promote tumor growth and malignant progression by activating …

Recent findings have identified critical roles for the actin filament-crosslinking protein filamin
A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA …