Nanotechnology in vaccine delivery

LJ Peek, CR Middaugh, C Berkland - Advanced drug delivery reviews, 2008 - Elsevier
With very few adjuvants currently being used in marketed human vaccines, a critical need
exists for novel immunopotentiators and delivery vehicles capable of eliciting humoral …

Engineering biodegradable polyester particles with specific drug targeting and drug release properties

F Mohamed, CF van der Walle - Journal of pharmaceutical sciences, 2008 - Elsevier
ABSTRACT Poly (lactic acid)(PLA) and poly (lactic‐co‐glycolic acid)(PLGA) microspheres
and nanoparticles remain the focus of intensive research effort directed to the controlled …

PLGA micro and nanoparticles in delivery of peptides and proteins; problems and approaches

S Mohammadi-Samani, B Taghipour - Pharmaceutical …, 2015 - Taylor & Francis
During the last decades, many of the poorly controlled diseases were treated using newly
developed peptide and proteins. Although the majority of such therapeutic moieties have …

Concurrent delivery of dexamethasone and VEGF for localized inflammation control and angiogenesis

SD Patil, F Papadmitrakopoulos, DJ Burgess - Journal of controlled release, 2007 - Elsevier
Localized elution of corticosteroids has been used in suppressing inflammation and fibrosis
associated with implantation and continuous in vivo residence of bio-medical devices …

Analysis of initial burst in PLGA microparticles

SD Allison - Expert opinion on drug delivery, 2008 - Taylor & Francis
Background: This review addresses recent advances in the understanding of the
mechanisms that underlie burst release and strategies developed to control burst from poly …

Encapsulation of protein drugs in biodegradable microparticles by co-axial electrospray

J Xie, WJ Ng, LY Lee, CH Wang - Journal of colloid and interface science, 2008 - Elsevier
A co-axial electrospray process was developed to encapsulate protein-based drugs in
biodegradable polymeric microparticles eliminating the key problem faced by other …

A freeze-dried formulation of bacteriophage encapsulated in biodegradable microspheres

U Puapermpoonsiri, J Spencer… - European Journal of …, 2009 - Elsevier
With the emergence of widespread antibiotic resistance, there has been renewed interest in
the use of bacteriophages. While their potency, safety and specificity have underpinned their …

Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability

F Qi, J Wu, Q Fan, F He, G Tian, T Yang, G Ma… - Colloids and surfaces B …, 2013 - Elsevier
Exenatide-loaded poly (d, l-lactic-co-glycolic acid)(PLGA) microspheres hold great potential
as a drug delivery system to treat type 2 diabetes mellitus (T2DM) because they can …

Bovine Serum Albumin Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery via Dry Powder Inhalation

NK Kunda, IM Alfagih, SR Dennison, HM Tawfeek… - Pharmaceutical …, 2015 - Springer
Purpose Dry powder vaccine delivery via the pulmonary route has gained significant
attention as an alternate route to parenteral delivery. In this study, we investigated bovine …

Biodegradable PLGA85/15 nanoparticles as a delivery vehicle for Chlamydia trachomatis recombinant MOMP-187 peptide

MA Taha, SR Singh, VA Dennis - Nanotechnology, 2012 - iopscience.iop.org
Abstract Development of a Chlamydia trachomatis vaccine has been a formidable task partly
because of an ineffective delivery system. Our laboratory has generated a recombinant …