Immunotherapy for lung cancer

A Steven, SA Fisher, BW Robinson - Respirology, 2016 - Wiley Online Library
Abstract Treatment of lung cancer remains a challenge, and lung cancer is still the leading
cause of cancer‐related mortality. Immunotherapy has previously failed in lung cancer but …

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

JG Pol, S Levesque, ST Workenhe, S Gujar… - …, 2018 - Taylor & Francis
Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus
supporting the establishment of therapeutically relevant tumor-specific immune responses …

Trial watch: immune checkpoint blockers for cancer therapy

C Vanpouille-Box, C Lhuillier, L Bezu, F Aranda… - …, 2017 - Taylor & Francis
Immune checkpoint blockers (ICBs) are literally revolutionizing the clinical management of
an ever more diversified panel of oncological indications. Although considerable attention …

Natural killer cells and dendritic cells: Expanding clinical relevance in the non-small cell lung cancer (NSCLC) tumor microenvironment

P Ahluwalia, M Ahluwalia, AK Mondal, NS Sahajpal… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the leading causes of mortality around the globe. In the
past decades, there has been rapid progress in the development of tools to detect, screen …

Nanoengineering a metal–organic framework for osteosarcoma chemo-immunotherapy by modulating indoleamine-2, 3-dioxygenase and myeloid-derived …

Q Fan, J Zuo, H Tian, C Huang, EC Nice, Z Shi… - Journal of Experimental …, 2022 - Springer
Background The high postoperative recurrence rate and refractoriness of relapsed tumors
are still a conundrum for the clinical management of osteosarcoma (OS). New therapeutic …

Combinatorial regimens of chemotherapeutic agents: A new perspective on raising the heat of the tumor immune microenvironment

J Liu, Y Yu, C Liu, C Gao, J Zhuang, L Liu… - Frontiers in …, 2022 - frontiersin.org
Harnessing the broad immunostimulatory capabilities of chemotherapy in combination with
immune checkpoint inhibitors has improved immunotherapy outcomes in patients with …

Clinical efficacy and future prospects of immunotherapy in lung cancer

T Kinoshita, H Terai, T Yaguchi - Life, 2021 - mdpi.com
The three major conventional treatments: surgery, chemotherapy, and radiation therapy,
have been commonly performed for lung cancer. However, lung cancer is still the leading …

Trial watch: immunostimulatory monoclonal antibodies for oncological indications

M Cabo, R Offringa, L Zitvogel, G Kroemer… - …, 2017 - Taylor & Francis
The goal of cancer immunotherapy is to establish new or boost pre-existing anticancer
immune responses that eradicate malignant cells while generating immunological memory …

Targeting tumor tolerance: A new hope for pancreatic cancer therapy?

D Delitto, SM Wallet, SJ Hughes - Pharmacology & therapeutics, 2016 - Elsevier
With a 5-year survival rate of just 8%, pancreatic cancer (PC) is projected to be the second
leading cause of cancer deaths by 2030. Most PC patients are not eligible for surgery with …

Monocytic myeloid-derived suppressor cells underpin resistance to adoptive T cell therapy in nasopharyngeal carcinoma

R Hopkins, W Xiang, D Marlier, VB Au, Q Ching… - Molecular Therapy, 2021 - cell.com
Advanced, late-stage Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) is
incurable, and its treatment remains a clinical and therapeutic challenge. Results from a …