The DNA and protein complex known as chromatin is subject to posttranslational
modifications (PTMs) that regulate cellular functions such that PTM dysregulation can lead to …

Spermatozoa (SPZ) are motile cells, characterized by a cargo of epigenetic information
including histone post-translational modifications (histone PTMs) and non-coding RNAs …

The ubiquitin proteasome system regulates meiotic recombination in yeast through its
association with the synaptonemal complex, a 'zipper'-like structure that holds homologous …

The recombinase RAD51 catalyzes the DNA strand exchange reaction in homologous
recombination (HR) during both mitosis and meiosis. However, the physiological role of …

Dibutyl phthalate (DBP), one of the most widely used plasticizers, is a known environmental
endocrine disruptor that impairs male and female fertility. In this study, oral administration of …

The accurate repair of DNA damage specifically the chromosomal double-strand breaks
(DSBs) arising from exposure to physical or chemical agents, such as ionizing radiation (IR) …

Deca-brominated diphenyl ether (BDE-209) is a common flame retardant utilized in
electronic products, textiles, furniture, and upholstery materials. Environmental BDE-209 …

Spermatogenesis is the process of generation of male reproductive cells from
spermatogonial stem cells in the seminiferous epithelium of the testis. During …

vinylcyclohexene diepoxide (VCD), widely used in industry, is a hazardous compound that
can cause premature ovarian failure, but whether maternal VCD exposure affects the health …

Paternal environmental perturbations, including cocaine intake, can affect the development
and behavior of the offspring through epigenetic inheritance. However, the mechanism by …