[HTML][HTML] Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target
Y Gao, NI Martin, MJ van Haren - Drug Discovery Today, 2021 - Elsevier
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (NA) to generate 1-
methyl nicotinamide. Since its discovery 70 years ago, the appreciation of the role of NNMT …
methyl nicotinamide. Since its discovery 70 years ago, the appreciation of the role of NNMT …
The development of small molecules targeting methyltransferase-like 3
H Li, Q Zhang, Q Feng, Q You, X Guo - Drug Discovery Today, 2023 - Elsevier
Abstract In mammals, N 6-methyladenosine (m 6 A) is thought to be the most common and
conserved mRNA modification. Methyltransferase-like 3 (METTL3) is the primary regulator of …
conserved mRNA modification. Methyltransferase-like 3 (METTL3) is the primary regulator of …
SETD3 is an actin histidine methyltransferase that prevents primary dystocia
For more than 50 years, the methylation of mammalian actin at histidine 73 has been known
to occur. Despite the pervasiveness of His73 methylation, which we find is conserved in …
to occur. Despite the pervasiveness of His73 methylation, which we find is conserved in …
Mutations in the pectin methyltransferase QUASIMODO2 influence cellulose biosynthesis and wall integrity in Arabidopsis
Pectins are abundant in the cell walls of dicotyledonous plants, but how they interact with
other wall polymers and influence wall integrity and cell growth has remained mysterious …
other wall polymers and influence wall integrity and cell growth has remained mysterious …
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
MettL3-MettL14 methyltransferase complex has been studied widely for its role in RNA
adenine methylation. This complex is also recruited to UV-and X-ray exposed DNA …
adenine methylation. This complex is also recruited to UV-and X-ray exposed DNA …
Mechanistic insights into m6A modification of U6 snRNA by human METTL16
T Aoyama, S Yamashita, K Tomita - Nucleic acids research, 2020 - academic.oup.com
The N6-methyladenosine modification at position 43 (m6A43) of U6 snRNA is catalyzed by
METTL16, and is important for the 5′-splice site recognition by U6 snRNA during pre …
METTL16, and is important for the 5′-splice site recognition by U6 snRNA during pre …
The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation
The de novo DNA methyltransferases Dnmt3a and Dnmt3b play crucial roles in
developmental and cellular processes. Their enzymatic activities are stimulated by a …
developmental and cellular processes. Their enzymatic activities are stimulated by a …
[HTML][HTML] PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
C Jiang, J Liu, S He, W Xu, R Huang, W Pan, X Li… - Cell Metabolism, 2023 - cell.com
Methionine is an essential branch of diverse nutrient inputs that dictate mTORC1 activation.
In the absence of methionine, SAMTOR binds to GATOR1 and inhibits mTORC1 signaling …
In the absence of methionine, SAMTOR binds to GATOR1 and inhibits mTORC1 signaling …
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present
three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core …
three high-resolution crystal structures of the SARS-CoV-2 nsp14 N7-methyltransferase core …
Development of macrocyclic PRMT5–adaptor protein interaction inhibitors
A Krzyzanowski, LM Esser, A Willaume… - Journal of Medicinal …, 2022 - ACS Publications
The PRMT5-MEP50 methyltransferase is a major target for anticancer drug discovery, and
modulators of its interactions with different regulatory proteins are in high demand because …
modulators of its interactions with different regulatory proteins are in high demand because …