Ca2+ plays a central role in the contraction of the heart. It is the bi-directional link between
electrical excitation of the heart and contraction. Electrical excitation initiates Ca2+ influx …

The sinoatrial node, whose cells (sinoatrial node cells [SANCs]) generate rhythmic action
potentials, is the primary pacemaker of the heart. During diastole, calcium released from the …

Risk stratification in the context of sudden cardiac death has been acknowledged as one of
the major challenges facing cardiology for the past four decades. In recent years, the advent …

In the world of cell biology, there is a myriad of oscillatory processes, with periods ranging
from the day of a circadian rhythm to the milliseconds of a neuronal action potential. To one …

Cardiovascular disease is a leading cause of death in developed countries, and places a
huge demand on healthcare services and economies across the globe. In this thesis …

Oscillations and travelling waves in the concentration of free cytosolic calcium are complex
dynamical phenomena that play vital roles in cellular function, controlling such processes as …