Association of the epithelial–mesenchymal transition (EMT) with cisplatin resistance

M Ashrafizadeh, A Zarrabi, K Hushmandi… - International journal of …, 2020 - mdpi.com
Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

PP2A as a master regulator of the cell cycle

N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

[HTML][HTML] Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating the PP2A-GSK3β-MCL-1 axis

M Elgendy, M Ciro, A Hosseini, J Weiszmann… - Cancer cell, 2019 - cell.com
Tumor cells may adapt to metabolic challenges by alternating between glycolysis and
oxidative phosphorylation (OXPHOS). To target this metabolic plasticity, we combined …

MYC degradation

AS Farrell, RC Sears - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
The MYC oncoprotein is an essential transcription factor that regulates the expression of
many genes involved in cell growth, proliferation, and metabolic pathways. Thus, it is …

All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase

J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

P Seshacharyulu, P Pandey, K Datta, SK Batra - Cancer letters, 2013 - Elsevier
Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine
threonine phosphatase and regulates the function by dephosphorylating many critical …

Mitotic tethering enables inheritance of shattered micronuclear chromosomes

P Trivedi, CD Steele, FKC Au, LB Alexandrov… - Nature, 2023 - nature.com
Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome (s),
is an ubiquitous mutational process generating localized and complex chromosomal …

Protein phosphatase 2A: a target for anticancer therapy

D Perrotti, P Neviani - The lancet oncology, 2013 - thelancet.com
Summary Protein phosphatase 2A (PP2A), one of the main serine–threonine phosphatases
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …

Micropeptide CIP 2A‐BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

B Guo, S Wu, X Zhu, L Zhang, J Deng, F Li… - The EMBO …, 2020 - embopress.org
TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …

MYC and therapy resistance in cancer: risks and opportunities

G Donati, B Amati - Molecular oncology, 2022 - Wiley Online Library
The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …