The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome
also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …

Activity-dependent transcriptional responses shape cortical function. However, a
comprehensive understanding of the diversity of these responses across the full range of …

Understanding how neural information is processed in physiological and pathological states
would benefit from precise detection, localization, and quantification of the activity of all …

Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

Exercise can improve cognitive function and has been linked to the increased expression of
brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms …