Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …

Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …

At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …

Insulin resistance leads to impaired glucose metabolism by disrupting both insulin secretion
and sensitivity. Insulin resistance plays a key role in the pathophysiology of type 2 diabetes …

The current study describes the discovery of novel inhibitors of α-glucosidase and α-
amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide …

Diabetes mellitus (DM) is a chronic metabolic disease, the third killer of mankind. The finding
of potent drugs against diabetes remains challenging. In the present study, coumarin …

In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …

Diabetes mellitus, a group of metabolic disorders characterized by persistent hyperglycemia,
affects millions of people worldwide and is on the rise. Dietary proteins, from a wide range of …