Protection against microbial infection in eukaryotes is provided by diverse cellular and
molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus …

RNA silencing is a homology-dependent gene inactivation mechanism that regulates a wide
range of biological processes including antiviral defense. To deal with host antiviral …

RNA silencing is a central regulator of gene expression in most eukaryotes and acts both at
the transcriptional level through DNA methylation and at the post-transcriptional level …

Plants have benefited from interactions with symbionts for coping with challenging
environments since the colonisation of land. The mechanisms of symbiont-mediated …

Viruses cause epidemics on all major cultures of agronomic importance, representing a
serious threat to global food security. As strict intracellular pathogens, they cannot be …

In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a
pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) …

Highlights•AGO1 and AGO2 are the two major plant antiviral ARGONAUTES against RNA
viruses.•AGOs bind virus-derived small RNAs to target complementary viral RNA or …

Adaptive antiviral immunity in plants is an RNA-based mechanism in which small RNAs
derived from both strands of the viral RNA are guides for an Argonaute (AGO) nuclease. The …

Background Among the environmental limitations that affect plant growth, viruses cause
major crop losses worldwide and represent serious threats to food security. Significant …

MicroRNAs are a class of non-coding small RNAs involved in the negative regulation of
gene expression, which play critical roles in developmental and metabolic pathways …