Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects
HVN Küsters‐Vandevelde, B Küsters… - Brain …, 2015 - Wiley Online Library
Primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of
rare tumors. They can be benign or malignant and occur in adults as well as in children, the …
rare tumors. They can be benign or malignant and occur in adults as well as in children, the …
Neurocutaneous melanocytosis (melanosis)
M Ruggieri, A Polizzi, S Catanzaro, ML Bianco… - Child's Nervous …, 2020 - Springer
Abstract Neurocutaneous melanosis (NCM; MIM# 249400; ORPHA: 2481], first reported by
the Bohemian pathologist Rokitansky in 1861, and now more precisely defined as …
the Bohemian pathologist Rokitansky in 1861, and now more precisely defined as …
Therapeutic Strategies in Neurocutaneous Melanocytosis
D Basu - Anticancer Research, 2024 - ar.iiarjournals.org
Neurocutaneous melanocytosis (NCM) is a rare, congenital condition primarily affecting
children, characterized by large or giant congenital melanocytic nevi (L/GCMN) on the skin …
children, characterized by large or giant congenital melanocytic nevi (L/GCMN) on the skin …
The dual PI3K/mToR inhibitor omipalisib/GSK2126458 inhibits clonogenic growth in oncogenically-transformed cells from neurocutaneous melanocytosis
D Basu, CM Salgado, B Bauer, Y Khakoo… - Cancer Genomics & …, 2018 - cgp.iiarjournals.org
Background: Omipalisib has been found to affect the viability of cancer cells. However, its
effect on clonogenicity–a feature of cancer stem cells, is not clear. Cells isolated from …
effect on clonogenicity–a feature of cancer stem cells, is not clear. Cells isolated from …
NRASQ61K mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications
G Angelino, MD De Pasquale, L De Sio, A Serra… - BMC cancer, 2016 - Springer
Background Primary melanocytic neoplasms are rare in the pediatric age. Among them, the
pattern of neoplastic meningitis represents a peculiar diagnostic challenge since …
pattern of neoplastic meningitis represents a peculiar diagnostic challenge since …
Nevospheres from neurocutaneous melanocytosis cells show reduced viability when treated with specific inhibitors of NRAS signaling pathway
D Basu, CM Salgado, BS Bauer, D Johnson… - Neuro …, 2015 - academic.oup.com
Background Neurocutaneous melanocytosis (NCM) is characterized by clonal
nevomelanocytic proliferations in the CNS and skin. Given the scarcity of effective …
nevomelanocytic proliferations in the CNS and skin. Given the scarcity of effective …
Severe hydrocephalus caused by diffuse leptomeningeal and neurocutaneous melanocytosis of antenatal onset: a clinical, pathologic, and molecular study of 2 cases
Diffuse leptomeningeal melanocytosis (DLM) is a rare nevomelanocytic proliferation arising
in the meninges. Despite their lack of morphological features of malignancy, these clonal …
in the meninges. Despite their lack of morphological features of malignancy, these clonal …
Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager
A Vanood, YA Lee, E Leleszi… - BMJ Case Reports …, 2020 - casereports.bmj.com
Neurocutaneous melanosis (NCM) is a rare disorder characterised by giant or multiple
melanocytic nevi and meningeal melanosis or melanoma. Onset of neurological symptoms …
melanocytic nevi and meningeal melanosis or melanoma. Onset of neurological symptoms …
Lin28A/let-7 oncogenic circuit is a potential therapeutic target in neurocutaneous melanosis-associated CNS tumors in children
This study aims to describe the initial findings on the implication of Lin28A oncoprotein in
rare and currently difficult to cure CNS tumors associated with neurocutaneous melanosis in …
rare and currently difficult to cure CNS tumors associated with neurocutaneous melanosis in …
Insulin-like growth factor 1 receptor signaling via Akt: a general therapeutic target in neurocutaneous melanocytosis?
Symptomatic neurocutaneous melanocytosis (NCM) currently has no therapy and bears an
extremely poor prognosis. Although first described by Rokitansky in 1861, information on …
extremely poor prognosis. Although first described by Rokitansky in 1861, information on …