Activation of autocrine and paracrine signalling by endothelin 1 (ET1) binding to its
receptors elicits pleiotropic effects on tumour cells and on the host microenvironment. This …

Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Collectively, the endothelins and their receptors—referred to as the endothelin (ET) axis—
have key physiological functions in normal tissue, acting as modulators of vasomotor tone …

Over the past decade cyclooxygenase-2-derived prostaglandins have been implicated in the
development and progression of many types of cancer. Recently our laboratory has shown …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Endothelin-1 is the most potent vasoconstrictor agent currently identified, and it was
originally isolated and characterized from the culture media of aortic endothelial cells. Two …

Cancer that arises from the ovarian surface epithelium (OSE) accounts for approximately
90% of human ovarian cancer, and is the fourth leading cause of cancer‐related deaths …

BACKGROUND. The objective of this study was to evaluate the efficacy and safety of
atrasentan (Xinlay), a selective endothelin‐A receptor antagonist, in patients with metastatic …

The ERBB or EGF receptor (EGFR) proto-oncogene family, which consists of four structurally-
related transmembrane receptors (ie, EGFR, ErbB2, ErbB3, and ErbB4), plays an etiological …