Antisense oligonucleotides: a novel Frontier in pharmacological strategy

D Collotta, I Bertocchi, E Chiapello… - Frontiers in …, 2023 - frontiersin.org
Antisense oligonucleotides (ASOs) are short single stranded synthetic RNA or DNA
molecules, whereas double-stranded RNA nucleotide sequences are called small …

Mechanisms coupling lipid droplets to MASLD pathophysiology

MV Reid, G Fredickson, DG Mashek - Hepatology, 2024 - journals.lww.com
Hepatic steatosis, the buildup of neutral lipids in lipid droplets (LDs), is commonly referred to
as metabolic dysfunction-associated steatotic liver disease (MASLD) when alcohol or viral …

[HTML][HTML] Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

Y Xia, E Andersson, SK Anand, E Cansby… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide
afflicting about one quarter of the adult population. NASH is a severe subtype of NAFLD …

STE20‐type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver …

M Caputo, Y Xia, SK Anand, E Cansby… - The FASEB …, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies.
Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis …

Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage

SK Anand, M Caputo, Y Xia, E Andersson… - Journal of Lipid …, 2022 - ASBMB
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD),
affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a …

[HTML][HTML] Antagonizing STK25 signaling suppresses the development of hepatocellular carcinoma through targeting metabolic, inflammatory, and pro-oncogenic …

Y Kurhe, M Caputo, E Cansby, Y Xia, S Kumari… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-
growing cancers. Recently, nonalcoholic steatohepatitis (NASH) has been recognized as a …

[PDF][PDF] STE20‐type protein kinase MST4 controls NAFLD progression by regulating lipid droplet dynamics and metabolic stress in hepatocytes

M Caputo, E Cansby, S Kumari, Y Kurhe… - Hepatology …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver
disease worldwide, primarily because of the massive global increase in obesity. Despite …

Antisense oligonucleotide is a promising intervention for liver diseases

K Lu, Q Fan, X Zou - Frontiers in Pharmacology, 2022 - frontiersin.org
As the body's critical metabolic organ, the liver plays an essential role in maintaining proper
body homeostasis. However, as people's living standards have improved and the number of …

Nuclear factor E2-associated factor 2 and musculoaponeurotic fibrosarcoma K mediate regulation glutathione peroxidase of Cristaria plicata after microcystin-induced …

X Cao, J An, S Zhu, M Feng, Y Gang, C Wen… - … and Physiology Part C …, 2023 - Elsevier
Nuclear factor E2-associated factor 2 (Nrf2)/Antioxidant Response Element (ARE) signaling
pathway is an endogenous antioxidant pathway that protects cells from oxidative damage …

[HTML][HTML] GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action

E Cansby, M Caputo, E Andersson, R Saghaleyni… - Journal of Lipid …, 2024 - Elsevier
Metabolic dysfunction–associated steatotic liver disease has emerged as a leading global
cause of chronic liver disease. Our recent translational investigations have shown that the …