Neuronal redevelopment and the regeneration of neuromodulatory axons in the adult mammalian central nervous system

P Cooke, H Janowitz, SE Dougherty - Frontiers in cellular …, 2022 - frontiersin.org
One reason that many central nervous system injuries, including those arising from traumatic
brain injury, spinal cord injury, and stroke, have limited recovery of function is that neurons …

Sex differences: Transcriptional signatures of stress exposure in male and female brains

E Brivio, JP Lopez, A Chen - Genes, brain and behavior, 2020 - Wiley Online Library
More than two‐thirds of patients suffering from stress‐related disorders are women but over
two‐thirds of suicide completers are men. These are just some examples of the many sex …

Precise temporal regulation of alternative splicing during neural development

SM Weyn-Vanhentenryck, H Feng… - Nature …, 2018 - nature.com
Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …

Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury

G Poplawski, T Ishikawa, C Brifault, C Lee‐Kubli… - Glia, 2018 - Wiley Online Library
Sensory neurons in the PNS demonstrate substantial capacity for regeneration following
injury. Recent studies have identified changes in the transcriptome of sensory neurons …

Effect of VEGF on inflammatory regulation, neural survival, and functional improvement in rats following a complete spinal cord transection

J Li, S Chen, Z Zhao, Y Luo, Y Hou, H Li… - Frontiers in cellular …, 2017 - frontiersin.org
After complete transection of the thoracic spinal segment, neonatal rats exhibit spontaneous
locomotor recovery of hindlimbs, but this recovery is not found in adult rats after similar …

Translatome regulation in neuronal injury and axon regrowth

M Rozenbaum, M Rajman, I Rishal, I Koppel, S Koley… - Eneuro, 2018 - eneuro.org
Transcriptional events leading to outgrowth of neuronal axons have been intensively
studied, but the role of translational regulation in this process is not well understood. Here …

Rapid-stretch injury to peripheral nerves: implications from an animal model

MA Mahan, WS Warner, S Yeoh, A Light - Journal of Neurosurgery, 2019 - thejns.org
OBJECTIVE Rapid-stretch nerve injuries are among the most devastating lesions to
peripheral nerves, yielding unsatisfactory functional outcomes. No animal model has yet …

Effects of electroacupuncture at governor vessel acupoints on neurotrophin‐3 in rats with experimental spinal cord injury

Y Mo, H Yao, W Lv, L Song, H Song, X Yuan… - Neural …, 2016 - Wiley Online Library
In an effort to explore new, noninvasive treatment options for spinal cord injuries (SCI), this
study investigated the effects of electroacupuncture (EA) for SCI rat models. SCI was …

Rapid-stretch injury to peripheral nerves: comparison of injury models

S Yeoh, WS Warner, I Eli, MA Mahan - Journal of Neurosurgery, 2020 - thejns.org
OBJECTIVE Traditional animal models of nerve injury use controlled crush or transection
injuries to investigate nerve regeneration; however, a more common and challenging …

Differential regenerative ability of sensory and motor neurons

M Cheah, JW Fawcett, B Haenzi - Neuroscience Letters, 2017 - Elsevier
After injury, the adult mammalian central nervous system (CNS) lacks long-distance axon
regeneration. This review discusses the similarities and differences of sensory and motor …