An overview of aryl hydrocarbon receptor ligands in the Last two decades (2002–2022): A medicinal chemistry perspective

L Lin, Y Dai, Y Xia - European Journal of Medicinal Chemistry, 2022 - Elsevier
The aryl hydrocarbon receptor (AhR), discovered 46 years ago, is a transcript factor member
of the basic helix-loop-helix Per-ARNT-SIM (bHLH-PAS) family deeply implicated in health …

The role of the aryl hydrocarbon receptor (AhR) and its ligands in breast cancer

S Safe, L Zhang - Cancers, 2022 - mdpi.com
Simple Summary The aryl hydrocarbon receptor (AhR) is expressed in breast cancer cells
and tumors and in some studies, the AhR is a negative prognostic factor for patient survival …

Prediction and screening model for products based on fusion regression and xgboost classification

J Wu, L Kong, M Yi, Q Chen, Z Cheng… - Computational …, 2022 - Wiley Online Library
Performance prediction based on candidates and screening based on predicted
performance value are the core of product development. For example, the performance …

Aryl hydrocarbon receptor as an anticancer target: An overview of ten years odyssey

H Hanieh, M Bani Ismail, MA Alfwuaires, HIM Ibrahim… - Molecules, 2023 - mdpi.com
Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor belonging to the
basic helix–loop–helix (bHLH)/per-Arnt-sim (PAS) superfamily, is traditionally known to …

Design, Synthesis, Docking, 2D‐QSAR Modelling, Anticancer and Antioxidant Evaluation of Some New Azo‐Compounds Derivatives and Investigation of Their …

EO Hamed, DA Elsayed, MG Assy… - ChemistrySelect, 2022 - Wiley Online Library
Abstract 2, 2′(2, 4‐dioxopentane‐3, 3‐diyl) bis (diazene‐2, 1‐diyl) dibenzoic acid was
produced in this work, which was derived from the coupling reaction between two moles of …

[HTML][HTML] QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition

R Ancuceanu, PC Popovici, D Drăgănescu, Ș Busnatu… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: HMG-CoA reductase is an enzyme that regulates the initial stage of
cholesterol synthesis, and its inhibitors are widely used in the treatment of cardiovascular …

Amino alcohols as potential antibiotic and antifungal leads

JR Baker, PJ Cossar, MAT Blaskovich, AG Elliott… - Molecules, 2022 - mdpi.com
Five focused compound libraries (forty-nine compounds), based on prior studies in our
laboratory were synthesized and screened for antibiotic and anti-fungal activity against S …

Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism

L Wu, M Wang, L Rong, W Wang, L Chen, Q Wu… - Journal of …, 2024 - Elsevier
Antibiotic resistance genes (ARGs) can be easily promoted by antibiotics, however, the
structural effects of antibiotics on the proliferation of ARGs dynamic and the associated …

QSAR Based Drug Repurposing: A New Paradigm in Breast Cancer Research

R Mohapatra, P Panda, SS Rout - Indian Journal of Pharmaceutical …, 2024 - ijper.org
Breast carcinoma is the world's most prevalent type of cancer. The building of predictive
cytotoxicity breast cancer models assists permanent synthetic activities and give critical …

Deregulation of drug metabolizing enzymes and transporters in cancer via altered aryl hydrocarbon receptor signaling

G Vázquez-Gómez, J Vondráček - Resistance in Hematologic …, 2025 - Elsevier
The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-
loop-helix Per-ARNT-Sim family of transcriptional regulators and a major regulator of …