Illuminating the oral microbiome and its host interactions: animal models of disease

G Hajishengallis - FEMS Microbiology Reviews, 2023 - academic.oup.com
Periodontitis and caries are driven by complex interactions between the oral microbiome
and host factors, ie inflammation and dietary sugars, respectively. Animal models have been …

Controlling Alveolar Bone Loss by Hydrogel‐Based Mitigation of Oral Dysbiosis and Bacteria‐Triggered Proinflammatory Immune Response

X Chen, H Huang, C Guo, X Zhu, J Chen… - Advanced Functional …, 2024 - Wiley Online Library
Periodontitis is a chronic infection where abnormal host‐microbiota interactions alter the oral
microbiome, trigger a proinflammatory immune response, and cause inflammatory alveolar …

Nel-like Molecule Type 1 Combined with gold nanoparticles modulates macrophage polarization, osteoclastogenesis, and oral Microbiota in periodontitis

W Liao, C Ni, R Ge, Y Li, S Jiang… - ACS Applied Materials …, 2024 - ACS Publications
The disruption of host–microbe homeostasis and uncontrolled inflammatory response have
been considered as vital causes for developing periodontitis, subsequently leading to an …

Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model

KL Kirkwood, TE Van Dyke… - Journal of Dental …, 2024 - journals.sagepub.com
There is a strong association between vitamin D levels and periodontal disease based on
numerous epidemiological studies. We have previously shown that experimental deficiency …

Association of Periodontitis and Atopic Dermatitis with the Levels of IL-13, IL-31, and TSLP in the Gingival Crevicular Fluid

C Jiménez, J Fernández, M Aroca… - International journal of …, 2023 - mdpi.com
Emerging epidemiological evidence links atopic dermatitis (AD) and periodontitis, although
the mechanisms remain unclear. Th2-derived cytokines are key in the development of both …

Blue Light-Emitting Diode Irradiation Without a Photosensitizer Alters Oral Microbiome Composition of Ligature-Induced Periodontitis in Mice

K Toyoshima, Y Ohsugi, P Lin, K Komatsu… - … , and Laser Surgery, 2023 - liebertpub.com
Objective: This study investigated the suppressive effects of blue light-emitting diode (LED)
irradiation on bone resorption and changes in the oral microbiome of mice with ligature …

Oral Inflammation and Microbiome Dysbiosis Exacerbate Chronic Graft-versus-host Disease

Y Kambara, H Fujiwara, A Yamamoto, K Gotoh, S Tsuji… - Blood, 2024 - Elsevier
The oral microbiota, second in abundance to the gut, is implicated in chronic systemic
diseases, but its specific role in GVHD pathogenesis has been unclear. Our study finds that …

Polybacterial Intracellular Macromolecules Shape Single-Cell Epikine Profiles in Upper Airway Mucosa

QT Easter, Z Alvarado-Martinez, M Kunz, B Matuck… - bioRxiv, 2024 - biorxiv.org
The upper airway, particularly the nasal and oral mucosal epithelium, serves as a primary
barrier for microbial interactions throughout life. Specialized niches like the anterior nares …