Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: From behavior to molecular mechanisms

JA Fitzgerald, S Könemann… - Environmental …, 2021 - Wiley Online Library
The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Asymmetry of the brain: development and implications

V Duboc, P Dufourcq, P Blader… - Annual review of …, 2015 - annualreviews.org
Although the left and right hemispheres of our brains develop with a high degree of
symmetry at both the anatomical and functional levels, it has become clear that subtle …

A neural m6A/Ythdf pathway is required for learning and memory in Drosophila

L Kan, S Ott, B Joseph, ES Park, W Dai… - Nature …, 2021 - nature.com
Epitranscriptomic modifications can impact behavior. Here, we used Drosophila
melanogaster to study N6-methyladenosine (m6A), the most abundant modification of …

The olfactory system of zebrafish as a model for the study of neurotoxicity and injury: implications for neuroplasticity and disease

E Calvo-Ochoa, CA Byrd-Jacobs - International journal of molecular …, 2019 - mdpi.com
The olfactory system, composed of the olfactory organs and the olfactory bulb, allows
organisms to interact with their environment and through the detection of odor signals …

Brain and behavioral asymmetry: A lesson from fish

ME Miletto Petrazzini, VA Sovrano… - Frontiers in …, 2020 - frontiersin.org
It is widely acknowledged that the left and right hemispheres of human brains display both
anatomical and functional asymmetries. For more than a century, brain and behavioral …

Left habenula mediates light-preference behavior in zebrafish via an asymmetrical visual pathway

B Zhang, Y Yao, H Zhang, K Kawakami, J Du - Neuron, 2017 - cell.com
Habenula (Hb) plays critical roles in emotion-related behaviors through integrating inputs
mainly from the limbic system and basal ganglia. However, Hb also receives inputs from …

Afferent connectivity of the zebrafish habenulae

KJ Turner, TA Hawkins, J Yáñez, R Anadón… - Frontiers in neural …, 2016 - frontiersin.org
The habenulae are bilateral nuclei located in the dorsal diencephalon that are conserved
across vertebrates. Here we describe the main afferents to the habenulae in larval and adult …

Left habenular activity attenuates fear responses in larval zebrafish

ER Duboué, E Hong, KC Eldred, ME Halpern - Current Biology, 2017 - cell.com
Fear responses are defensive states that ensure survival of an organism in the presence of a
threat. Perception of an aversive cue causes changes in behavior and physiology, such as …

Specialized neurons in the right habenula mediate response to aversive olfactory cues

JH Choi, ER Duboue, M Macurak, JM Chanchu… - Elife, 2021 - elifesciences.org
Hemispheric specializations are well studied at the functional level but less is known about
the underlying neural mechanisms. We identified a small cluster of cholinergic neurons in …

Unmasking the relevance of hemispheric asymmetries—Break on through (to the other side)

M Esteves, SS Lopes, A Almeida, N Sousa… - Progress in …, 2020 - Elsevier
The pioneer works of Marc Dax and Paul Broca on the association between left hemisphere
injuries and speech impairments, revealed one of the most intriguing properties of the brain …